Please use this identifier to cite or link to this item: https://doi.org/10.3389/fendo.2022.1008329
Title: Plasma tissue factor coagulation activity in post-acute myocardial infarction patients
Authors: Lim, Xiong Chang
Yatim, Siti Maryam JM
Chong, Suet Yen 
Wang, Xiaoyuan 
Tan, Sock Hwee 
Yang, Xiaoxun 
Chan, Siew Pang 
Richards, A Mark 
Charles, Chris J
Chan, Mark Y 
Wang, Jiong-Wei 
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
tissue factor activity
acute myocardial infarction
left ventricular remodeling
heart failure
coagulation
FACTOR PATHWAY INHIBITOR
VON-WILLEBRAND-FACTOR
ACTIVATED FACTOR-XI
PROGNOSTIC VALUE
IN-VIVO
HEART
INTERLEUKIN-6
THROMBOSIS
MONOCYTES
WARFARIN
Issue Date: 23-Sep-2022
Publisher: FRONTIERS MEDIA SA
Citation: Lim, Xiong Chang, Yatim, Siti Maryam JM, Chong, Suet Yen, Wang, Xiaoyuan, Tan, Sock Hwee, Yang, Xiaoxun, Chan, Siew Pang, Richards, A Mark, Charles, Chris J, Chan, Mark Y, Wang, Jiong-Wei (2022-09-23). Plasma tissue factor coagulation activity in post-acute myocardial infarction patients. FRONTIERS IN ENDOCRINOLOGY 13. ScholarBank@NUS Repository. https://doi.org/10.3389/fendo.2022.1008329
Abstract: Introduction: Coagulation is involved in fibroproliferative responses following acute myocardial infarction (AMI). Left ventricular (LV) remodeling following AMI is closely associated with progression to heart failure. This study aims to assess the association between plasma tissue factor activity and LV remodeling in post-AMI patients. Methods: We studied 228 patients with AMI and 57 healthy subjects. Patients with AMI were categorized into two age- and sex-matched groups: patients with adverse LV remodeling or reverse LV remodeling, defined by an increase or decrease, respectively, in LV end systolic volume by ≥15% over 6 months. TF activity was measured in plasma collected at baseline (within 72 hours of revascularization), 1 month and 6 months post-AMI. Multiple level longitudinal data analysis with structural equation (ML-SEM) model was used to assess the impact of various clinical variables on TF activity in post-AMI. Results: Plasma TF activity in post-AMI patients at baseline (29.05 ± 10.75 pM) was similar to that in healthy subjects but fell at 1 month (21.78 ± 8.23, p<0.001) with partial recovery by 6 months (25.84 ± 8.80, p<0.001) after AMI. Plasma TF activity at 6 month post-AMI was better restored in patients with reverse LV remodeling than those with adverse LV remodeling (27.35 ± 7.14 vs 24.34 ± 9.99; p=0.009) independent of gender, age and relevant cardiovascular risk factors. Conclusions: Plasma TF activity decreased after AMI but was better restored at 6 months in patients with reverse LV remodeling. The clinical significance of changes in post-AMI plasma TF activity needs further investigation.
Source Title: FRONTIERS IN ENDOCRINOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/234463
ISSN: 1664-2392
DOI: 10.3389/fendo.2022.1008329
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