Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells10112925
Title: The multiple interactions of RUNX with the hippo–YAP pathway
Authors: Chuang, Linda Shyue Huey 
Ito, Yoshiaki 
Keywords: Cancer
Hippo
RUNX1
RUNX2
RUNX3
TAZ
YAP
Issue Date: 28-Oct-2021
Publisher: MDPI
Citation: Chuang, Linda Shyue Huey, Ito, Yoshiaki (2021-10-28). The multiple interactions of RUNX with the hippo–YAP pathway. Cells 10 (11) : 2925. ScholarBank@NUS Repository. https://doi.org/10.3390/cells10112925
Rights: Attribution 4.0 International
Abstract: The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/ maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis and metastasis. The Hippo pathway represses the activity of YAP and paralog TAZ by modulating cell proliferation and promoting differentiation to maintain tissue homeostasis and proper organ size. Similarly, master regulators of development RUNX transcription factors have been shown to play critical roles in proliferation, differentiation, apoptosis and cell fate determination. In this review, we discuss the multiple interactions of RUNX with the Hippo–YAP pathway, their shared collaborators in Wnt, TGF?, MYC and RB pathways, and their overlapping functions in development and tumorigenesis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Cells
URI: https://scholarbank.nus.edu.sg/handle/10635/233626
ISSN: 2073-4409
DOI: 10.3390/cells10112925
Rights: Attribution 4.0 International
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