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Title: Ultrasound and microbubbles for the treatment of ocular diseases: From preclinical research towards clinical application
Authors: Rousou, Charis
Schuurmans, Carl C. L.
Urtti, Arto
Mastrobattista, Enrico
Storm, Gert 
Moonen, Chrit
Kaarniranta, Kai
Deckers, Roel
Keywords: Blood–retina barrier
Cellular drug delivery
Drug delivery
Ocular drug delivery
Issue Date: 25-Oct-2021
Publisher: MDPI
Citation: Rousou, Charis, Schuurmans, Carl C. L., Urtti, Arto, Mastrobattista, Enrico, Storm, Gert, Moonen, Chrit, Kaarniranta, Kai, Deckers, Roel (2021-10-25). Ultrasound and microbubbles for the treatment of ocular diseases: From preclinical research towards clinical application. Pharmaceutics 13 (11) : 1782. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The unique anatomy of the eye and the presence of various biological barriers make efficacious ocular drug delivery challenging, particularly in the treatment of posterior eye diseases. This review focuses on the combination of ultrasound and microbubbles (USMB) as a minimally invasive method to improve the efficacy and targeting of ocular drug delivery. An extensive overview is given of the in vitro and in vivo studies investigating the mechanical effects of ultrasound-driven microbubbles aiming to: (i) temporarily disrupt the blood–retina barrier in order to enhance the delivery of systemically administered drugs into the eye, (ii) induce intracellular uptake of anticancer drugs and macromolecules and (iii) achieve targeted delivery of genes, for the treatment of ocular malignancies and degenerative diseases. Finally, the safety and tolerability aspects of USMB, essential for the translation of USMB to the clinic, are discussed. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Pharmaceutics
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics13111782
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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