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Title: Characteristics of epigenetic aging across gestational and perinatal tissues
Authors: Dieckmann, Linda
Lahti-Pulkkinen, Marius
Kvist, Tuomas
Lahti, Jari
DeWitt, Peter E.
Cruceanu, Cristiana
Laivuori, Hannele
Sammallahti, Sara
Villa, Pia M.
Suomalainen-König, Sanna
Eriksson, Johan G. 
Kajantie, Eero
Raikkönen, Katri
Binder, Elisabeth B.
Czamara, Darina
Keywords: Chorionic villi
Cord blood
Early development
Epigenetic age
Epigenetic clocks
Perinatal tissues
Issue Date: 29-Apr-2021
Publisher: BioMed Central Ltd
Citation: Dieckmann, Linda, Lahti-Pulkkinen, Marius, Kvist, Tuomas, Lahti, Jari, DeWitt, Peter E., Cruceanu, Cristiana, Laivuori, Hannele, Sammallahti, Sara, Villa, Pia M., Suomalainen-König, Sanna, Eriksson, Johan G., Kajantie, Eero, Raikkönen, Katri, Binder, Elisabeth B., Czamara, Darina (2021-04-29). Characteristics of epigenetic aging across gestational and perinatal tissues. Clinical Epigenetics 13 (1) : 97. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variables are most important in predicting gestational epigenetic age acceleration or deceleration (i.e., the deviation between gestational epigenetic age estimated from the DNA methylome and chronological gestational age) in chorionic villus, placenta and cord blood tissues from two independent study cohorts (ITU, n = 639 and PREDO, n = 966). We further characterized the correspondence of epigenetic age deviations between these tissues. Results: Among the most predictive factors of epigenetic age deviations in single tissues were child sex, birth length, maternal smoking during pregnancy, maternal mental disorders until childbirth, delivery mode and parity. However, the specific factors related to epigenetic age deviation and the direction of association differed across tissues. In individuals with samples available from more than one tissue, relative epigenetic age deviations were not correlated across tissues. Conclusion: Gestational epigenetic age acceleration or deceleration was not related to more favorable or unfavorable factors in one direction in the investigated tissues, and the relative epigenetic age differed between tissues of the same person. This indicates that epigenetic age deviations associate with distinct, tissue specific, factors during the gestational and perinatal period. Our findings suggest that the epigenetic age of the newborn should be seen as a characteristic of a specific tissue, and less as a general characteristic of the child itself. © 2021, The Author(s).
Source Title: Clinical Epigenetics
ISSN: 1868-7075
DOI: 10.1186/s13148-021-01080-y
Rights: Attribution 4.0 International
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