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Title: A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma
Authors: Zhou, Xiang
Cao, Su-Mei
Cai, Yong-Lin
Zhang, Xiao
Zhang, Shanshan
Feng, Guo-Fei
Chen, Yufeng
Feng, Qi-Sheng
Chen, Yijun
Chang, Ellen T.
Liu, Zhonghua
Adami, Hans-Olov
Liu, Jianjun 
Ye, Weimin
Zhang, Zhe
Zeng, Yi-Xin
Xu, Miao
Issue Date: 31-Aug-2021
Publisher: Nature Research
Citation: Zhou, Xiang, Cao, Su-Mei, Cai, Yong-Lin, Zhang, Xiao, Zhang, Shanshan, Feng, Guo-Fei, Chen, Yufeng, Feng, Qi-Sheng, Chen, Yijun, Chang, Ellen T., Liu, Zhonghua, Adami, Hans-Olov, Liu, Jianjun, Ye, Weimin, Zhang, Zhe, Zeng, Yi-Xin, Xu, Miao (2021-08-31). A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma. Nature Communications 12 (1) : 5189. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12–37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC. © 2021, The Author(s).
Source Title: Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25402-z
Rights: Attribution 4.0 International
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