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Title: Surface-modified highly biocompatible bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A review on the promising next-generation biomaterial
Authors: Chai, Jun Meng
Amelia, Tan Suet May
Mouriya, Govindan Kothandaraman
Bhubalan, Kesaven
Amirul, Al-Ashraf Abdullah
Vigneswari, Sevakumaran
Ramakrishna, Seeram 
Keywords: Biocompatible
Biomedical applications
Surface modifications
Tissue engineering
Issue Date: 25-Dec-2020
Publisher: MDPI AG
Citation: Chai, Jun Meng, Amelia, Tan Suet May, Mouriya, Govindan Kothandaraman, Bhubalan, Kesaven, Amirul, Al-Ashraf Abdullah, Vigneswari, Sevakumaran, Ramakrishna, Seeram (2020-12-25). Surface-modified highly biocompatible bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A review on the promising next-generation biomaterial. Polymers 13 (1) : 1-21. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are syn-thesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [(P(3HB-co-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-co-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-co-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-co-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-co-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-co-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Polymers
ISSN: 2073-4360
DOI: 10.3390/polym13010051
Rights: Attribution 4.0 International
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