Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fimmu.2021.674279
DC Field | Value | |
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dc.title | A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 | |
dc.contributor.author | Yeo, Joo Guan | |
dc.contributor.author | Leong, Jing Yao | |
dc.contributor.author | Tay, Shi Huan | |
dc.contributor.author | Nadua, Karen Donceras | |
dc.contributor.author | Anderson, Danielle E. | |
dc.contributor.author | Lim, Amanda Jin Mei | |
dc.contributor.author | Ng, Xiang Wen | |
dc.contributor.author | Poh, Su Li | |
dc.contributor.author | Guo, Dianyan | |
dc.contributor.author | Yaung, Katherine Nay | |
dc.contributor.author | Kumar, Pavanish | |
dc.contributor.author | Wasser, Martin | |
dc.contributor.author | Hazirah, Sharifah Nur | |
dc.contributor.author | Sutamam, Nursyuhadah | |
dc.contributor.author | Chua, Camillus Jian Hui | |
dc.contributor.author | Qui, Martin | |
dc.contributor.author | Foo, Randy | |
dc.contributor.author | Gamage, Akshamal Mihiranga | |
dc.contributor.author | Yeo, Kee Thai | |
dc.contributor.author | Ramakrishna, Lakshmi | |
dc.contributor.author | Arkachaisri, Thaschawee | |
dc.contributor.author | Young, Barnaby E. | |
dc.contributor.author | Lye, David Chien | |
dc.contributor.author | Wang, Lin-Fa | |
dc.contributor.author | Chong, Chia Yin | |
dc.contributor.author | Tan, Natalie Woon Hui | |
dc.contributor.author | Li, Jiahui | |
dc.contributor.author | Kam, Kai-Qian | |
dc.contributor.author | Ginhoux, Florent | |
dc.contributor.author | Thoon, Koh Cheng | |
dc.contributor.author | Chan, Jerry Kok Yen | |
dc.contributor.author | Yung, Chee Fu | |
dc.contributor.author | Albani, Salvatore | |
dc.date.accessioned | 2022-10-13T07:37:47Z | |
dc.date.available | 2022-10-13T07:37:47Z | |
dc.date.issued | 2021-05-25 | |
dc.identifier.citation | Yeo, Joo Guan, Leong, Jing Yao, Tay, Shi Huan, Nadua, Karen Donceras, Anderson, Danielle E., Lim, Amanda Jin Mei, Ng, Xiang Wen, Poh, Su Li, Guo, Dianyan, Yaung, Katherine Nay, Kumar, Pavanish, Wasser, Martin, Hazirah, Sharifah Nur, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Qui, Martin, Foo, Randy, Gamage, Akshamal Mihiranga, Yeo, Kee Thai, Ramakrishna, Lakshmi, Arkachaisri, Thaschawee, Young, Barnaby E., Lye, David Chien, Wang, Lin-Fa, Chong, Chia Yin, Tan, Natalie Woon Hui, Li, Jiahui, Kam, Kai-Qian, Ginhoux, Florent, Thoon, Koh Cheng, Chan, Jerry Kok Yen, Yung, Chee Fu, Albani, Salvatore (2021-05-25). A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Frontiers in Immunology 12 : 674279. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2021.674279 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/233189 | |
dc.description.abstract | An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFN?+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection. © Copyright © 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani. | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2021 | |
dc.subject | COVID-19 | |
dc.subject | follicular helper T cells | |
dc.subject | mass cytometry | |
dc.subject | regulatory T cells | |
dc.subject | SARS-CoV-2 | |
dc.type | Article | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | DUKE-NUS OFFICE OF ACAD & CLINICAL DEVT | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.description.doi | 10.3389/fimmu.2021.674279 | |
dc.description.sourcetitle | Frontiers in Immunology | |
dc.description.volume | 12 | |
dc.description.page | 674279 | |
Appears in Collections: | Elements Staff Publications |
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