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dc.titleA Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
dc.contributor.authorYeo, Joo Guan
dc.contributor.authorLeong, Jing Yao
dc.contributor.authorTay, Shi Huan
dc.contributor.authorNadua, Karen Donceras
dc.contributor.authorAnderson, Danielle E.
dc.contributor.authorLim, Amanda Jin Mei
dc.contributor.authorNg, Xiang Wen
dc.contributor.authorPoh, Su Li
dc.contributor.authorGuo, Dianyan
dc.contributor.authorYaung, Katherine Nay
dc.contributor.authorKumar, Pavanish
dc.contributor.authorWasser, Martin
dc.contributor.authorHazirah, Sharifah Nur
dc.contributor.authorSutamam, Nursyuhadah
dc.contributor.authorChua, Camillus Jian Hui
dc.contributor.authorQui, Martin
dc.contributor.authorFoo, Randy
dc.contributor.authorGamage, Akshamal Mihiranga
dc.contributor.authorYeo, Kee Thai
dc.contributor.authorRamakrishna, Lakshmi
dc.contributor.authorArkachaisri, Thaschawee
dc.contributor.authorYoung, Barnaby E.
dc.contributor.authorLye, David Chien
dc.contributor.authorWang, Lin-Fa
dc.contributor.authorChong, Chia Yin
dc.contributor.authorTan, Natalie Woon Hui
dc.contributor.authorLi, Jiahui
dc.contributor.authorKam, Kai-Qian
dc.contributor.authorGinhoux, Florent
dc.contributor.authorThoon, Koh Cheng
dc.contributor.authorChan, Jerry Kok Yen
dc.contributor.authorYung, Chee Fu
dc.contributor.authorAlbani, Salvatore
dc.identifier.citationYeo, Joo Guan, Leong, Jing Yao, Tay, Shi Huan, Nadua, Karen Donceras, Anderson, Danielle E., Lim, Amanda Jin Mei, Ng, Xiang Wen, Poh, Su Li, Guo, Dianyan, Yaung, Katherine Nay, Kumar, Pavanish, Wasser, Martin, Hazirah, Sharifah Nur, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Qui, Martin, Foo, Randy, Gamage, Akshamal Mihiranga, Yeo, Kee Thai, Ramakrishna, Lakshmi, Arkachaisri, Thaschawee, Young, Barnaby E., Lye, David Chien, Wang, Lin-Fa, Chong, Chia Yin, Tan, Natalie Woon Hui, Li, Jiahui, Kam, Kai-Qian, Ginhoux, Florent, Thoon, Koh Cheng, Chan, Jerry Kok Yen, Yung, Chee Fu, Albani, Salvatore (2021-05-25). A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Frontiers in Immunology 12 : 674279. ScholarBank@NUS Repository.
dc.description.abstractAn accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFN?+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection. © Copyright © 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2021
dc.subjectfollicular helper T cells
dc.subjectmass cytometry
dc.subjectregulatory T cells
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDUKE-NUS OFFICE OF ACAD & CLINICAL DEVT
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.sourcetitleFrontiers in Immunology
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