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Title: A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19
Authors: Yeo, Joo Guan 
Leong, Jing Yao 
Tay, Shi Huan
Nadua, Karen Donceras 
Anderson, Danielle E. 
Lim, Amanda Jin Mei
Ng, Xiang Wen
Poh, Su Li
Guo, Dianyan
Yaung, Katherine Nay
Kumar, Pavanish
Wasser, Martin 
Hazirah, Sharifah Nur
Sutamam, Nursyuhadah
Chua, Camillus Jian Hui
Qui, Martin
Foo, Randy 
Gamage, Akshamal Mihiranga 
Yeo, Kee Thai 
Ramakrishna, Lakshmi
Arkachaisri, Thaschawee 
Young, Barnaby E.
Lye, David Chien 
Wang, Lin-Fa 
Chong, Chia Yin 
Tan, Natalie Woon Hui 
Li, Jiahui 
Kam, Kai-Qian 
Ginhoux, Florent 
Thoon, Koh Cheng 
Chan, Jerry Kok Yen 
Yung, Chee Fu 
Albani, Salvatore 
Keywords: COVID-19
follicular helper T cells
mass cytometry
regulatory T cells
Issue Date: 25-May-2021
Publisher: Frontiers Media S.A.
Citation: Yeo, Joo Guan, Leong, Jing Yao, Tay, Shi Huan, Nadua, Karen Donceras, Anderson, Danielle E., Lim, Amanda Jin Mei, Ng, Xiang Wen, Poh, Su Li, Guo, Dianyan, Yaung, Katherine Nay, Kumar, Pavanish, Wasser, Martin, Hazirah, Sharifah Nur, Sutamam, Nursyuhadah, Chua, Camillus Jian Hui, Qui, Martin, Foo, Randy, Gamage, Akshamal Mihiranga, Yeo, Kee Thai, Ramakrishna, Lakshmi, Arkachaisri, Thaschawee, Young, Barnaby E., Lye, David Chien, Wang, Lin-Fa, Chong, Chia Yin, Tan, Natalie Woon Hui, Li, Jiahui, Kam, Kai-Qian, Ginhoux, Florent, Thoon, Koh Cheng, Chan, Jerry Kok Yen, Yung, Chee Fu, Albani, Salvatore (2021-05-25). A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Frontiers in Immunology 12 : 674279. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFN?+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection. © Copyright © 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani.
Source Title: Frontiers in Immunology
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.674279
Rights: Attribution 4.0 International
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