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Title: Phema: An overview for biomedical applications
Authors: Zare, Mina
Bigham, Ashkan
Zare, Mohamad
Luo, Hongrong
Rezvani Ghomi, Erfan
Ramakrishna, Seeram 
Keywords: Antimicrobial strategies
Biomedical application
Cancer therapy
Contact lens
Ocular drug delivery
Tissue engineering and regenerative medicine
Issue Date: 15-Jun-2021
Publisher: MDPI
Citation: Zare, Mina, Bigham, Ashkan, Zare, Mohamad, Luo, Hongrong, Rezvani Ghomi, Erfan, Ramakrishna, Seeram (2021-06-15). Phema: An overview for biomedical applications. International Journal of Molecular Sciences 22 (12) : 6376. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Poly(2-hydroxyethyl methacrylate) (pHEMA) as a biomaterial with excellent biocompati-bility and cytocompatibility elicits a minimal immunological response from host tissue making it desirable for different biomedical applications. This article seeks to provide an in-depth overview of the properties and biomedical applications of pHEMA for bone tissue regeneration, wound healing, cancer therapy (stimuli and non-stimuli responsive systems), and ophthalmic applications (contact lenses and ocular drug delivery). As this polymer has been widely applied in ophthalmic applications, a specific consideration has been devoted to this field. Pure pHEMA does not possess antimicrobial properties and the site where the biomedical device is employed may be susceptible to microbial infections. Therefore, antimicrobial strategies such as the use of silver nanoparticles, antibiotics, and antimicrobial agents can be utilized to protect against infections. Therefore, the antimicrobial strategies besides the drug delivery applications of pHEMA were covered. With continuous research and advancement in science and technology, the outlook of pHEMA is promising as it will most certainly be utilized in more biomedical applications in the near future. The aim of this review was to bring together state-of-the-art research on pHEMA and their applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms22126376
Rights: Attribution 4.0 International
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