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Title: Antimicrobial peptides and their applications in biomedical sector
Authors: Sultana, Afreen
Luo, Hongrong
Ramakrishna, Seeram 
Keywords: Anti-inflammatory
Antimicrobial activity
Antimicrobial peptides
Biomedical application
Functions of AMP
Immunomodulatory effect
Implementation techniques
Wound healing
Issue Date: 10-Sep-2021
Publisher: MDPI
Citation: Sultana, Afreen, Luo, Hongrong, Ramakrishna, Seeram (2021-09-10). Antimicrobial peptides and their applications in biomedical sector. Antibiotics 10 (9) : 1094. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: In a report by WHO (2014), it was stated that antimicrobial resistance is an arising chal-lenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNF?, IL-8, and IL-1?, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antibiotics
ISSN: 2079-6382
DOI: 10.3390/antibiotics10091094
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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