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Title: Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia
Authors: Supian, Nur Izzati
Ng, Kim Tien 
Chook, Jack Bee
Takebe, Yutaka
Chan, Kok Gan
Tee, Kok Keng
Keywords: Acute respiratory tract infections
Issue Date: 17-May-2021
Publisher: BioMed Central Ltd
Citation: Supian, Nur Izzati, Ng, Kim Tien, Chook, Jack Bee, Takebe, Yutaka, Chan, Kok Gan, Tee, Kok Keng (2021-05-17). Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia. BMC Infectious Diseases 21 (1) : 446. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans. Methods: A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia. Results: Epidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time. Conclusions: The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks. © 2021, The Author(s).
Source Title: BMC Infectious Diseases
ISSN: 1471-2334
DOI: 10.1186/s12879-021-06148-x
Rights: Attribution 4.0 International
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