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Title: Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2
Authors: Yenamandra, Surya Pavan
Koo, Carmen
Chiang, Suzanna
Lim, Han Shi Jeri
Yeo, Zhen Yuan 
Ng, Lee Ching
Hapuarachchi, Hapuarachchige Chanditha
Issue Date: 29-Jun-2021
Publisher: Nature Research
Citation: Yenamandra, Surya Pavan, Koo, Carmen, Chiang, Suzanna, Lim, Han Shi Jeri, Yeo, Zhen Yuan, Ng, Lee Ching, Hapuarachchi, Hapuarachchige Chanditha (2021-06-29). Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2. Scientific Reports 11 (1) : 13496. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within E gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations. © 2021, The Author(s).
Source Title: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-92783-y
Rights: Attribution 4.0 International
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