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Title: Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy
Authors: Cai, Xuzi
Wang, Kang-Nan
Ma, Wen
Yang, Yuanyuan
Chen, Gui
Fu, Huijiao
Cui, Chunhui
Yu, Zhiqiang
Wang, Xuefeng
Keywords: Cyclometalated iridium nanoparticles
Fluorescence imaging
Photodynamic therapy
Two-photon excitation
Issue Date: 23-Aug-2021
Publisher: BioMed Central Ltd
Citation: Cai, Xuzi, Wang, Kang-Nan, Ma, Wen, Yang, Yuanyuan, Chen, Gui, Fu, Huijiao, Cui, Chunhui, Yu, Zhiqiang, Wang, Xuefeng (2021-08-23). Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy. Journal of Nanobiotechnology 19 (1) : 254. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Developing novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challenge because of the poor water solubility, low reactive oxygen species (ROS) generation efficiency, serve dark cytotoxicity, and weak absorption in the NIR region of conventional photosensitizers. Herein, cyclometalated iridium (III) complexes (Ir) with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photon excitation, and mitochondria-targeting capability were designed and further encapsulated into biocompatible nanoparticles (NPs). The Ir-NPs can be used to disturb redox homeostasis in vitro, result in mitochondrial dysfunction and cell apoptosis. Importantly, in vivo experiments demonstrated that the Ir-NPs presented obviously tumor-targeting ability, excellent antitumor effect, and low systematic dark-toxicity. Moreover, the Ir-NPs could serve as a two-photon imaging agent for deep tissue bioimaging with a penetration depth of up to 300 ?m. This work presents a promising strategy for designing a clinical application of multifunctional Ir-NPs toward bioimaging and PDT. [Figure not available: see fulltext.]. © 2021, The Author(s).
Source Title: Journal of Nanobiotechnology
ISSN: 1477-3155
DOI: 10.1186/s12951-021-01001-4
Rights: Attribution 4.0 International
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