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Title: Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study
Authors: Eriksson, Mia D.
Eriksson, Johan G. 
Kautiainen, Hannu
Salonen, Minna K.
Mikkola, Tuija M.
Kajantie, Eero
Wasenius, Niko
Von Bonsdorff, Mikaela
Laine, Merja K.
Keywords: Advanced glycation end products
Cohort studies
Depressive disorder
Issue Date: 1-Jun-2021
Publisher: Elsevier Inc.
Citation: Eriksson, Mia D., Eriksson, Johan G., Kautiainen, Hannu, Salonen, Minna K., Mikkola, Tuija M., Kajantie, Eero, Wasenius, Niko, Von Bonsdorff, Mikaela, Laine, Merja K. (2021-06-01). Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms – Findings from Helsinki Birth Cohort Study. Journal of Psychosomatic Research 145 : 110488. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms. Methods: From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex. Results: Of women, 27% scored ?10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model. Conclusions: The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study. © 2021 The Author(s)
Source Title: Journal of Psychosomatic Research
ISSN: 0022-3999
DOI: 10.1016/j.jpsychores.2021.110488
Rights: Attribution 4.0 International
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