Please use this identifier to cite or link to this item: https://doi.org/10.1177/03331024211024166
Title: A national Swedish case-control study investigating incidence and factors associated with idiopathic intracranial hypertension
Authors: Sundholm, Anna
Burkill, Sarah 
Waldenlind, Elisabet
Bahmanyar, Shahram
Nilsson Remahl, A.I.M.
Keywords: case-control study
Idiopathic intracranial hypertension
incidence
pseudotumor cerebri syndrome
risk factors
Issue Date: 18-Aug-2021
Publisher: SAGE Publications Ltd
Citation: Sundholm, Anna, Burkill, Sarah, Waldenlind, Elisabet, Bahmanyar, Shahram, Nilsson Remahl, A.I.M. (2021-08-18). A national Swedish case-control study investigating incidence and factors associated with idiopathic intracranial hypertension. Cephalalgia 41 (14) : 1427-1436. ScholarBank@NUS Repository. https://doi.org/10.1177/03331024211024166
Rights: Attribution 4.0 International
Abstract: Objective: To study the incidence of idiopathic intracranial hypertension in Sweden and to explore whether previously proposed risk factors are associated with idiopathic intracranial hypertension by investigating the odds of exposure one year prior to diagnosis in patients compared to controls. Methods: Using Swedish health care registers and validated diagnostic algorithms, idiopathic intracranial hypertension patients diagnosed between 2000–2016 were compared with randomly selected matched controls, five from the general population and five with obesity. Results: We identified 902 idiopathic intracranial hypertension patients and 4510 matched individuals in each control group. Mean incidence among inhabitants ?18 years of age was 0.71 per 100,000; rising from 0.53 in 2000–2005 to 0.95 in 2012–2016. There were increased odds for idiopathic intracranial hypertension patients compared to general population for exposure to: kidney failure (odds ratio =13.2 (4.1–42.0)), arterial hypertension (odds ratio =17.5 (10.5–29.3)), systemic lupus erythematosus (odds ratio =13.8 (4.3–44.7)), tetracyclines, sulphonamides, lithium, and corticosteroids. In obese controls, odds ratios were also significantly increased for these exposures. Hormonal contraceptive use and exposure to pregnancy did not appear to be associated factors for idiopathic intracranial hypertension development. Conclusions: The incidence of idiopathic intracranial hypertension in Sweden is lower relative to reports from other countries but is on the rise. This case-control study confirms several previously reported risk factors associated with idiopathic intracranial hypertension. © International Headache Society 2021.
Source Title: Cephalalgia
URI: https://scholarbank.nus.edu.sg/handle/10635/232892
ISSN: 0333-1024
DOI: 10.1177/03331024211024166
Rights: Attribution 4.0 International
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