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Title: Editing SOX genes by CRISPR-cas: Current insights and future perspectives
Authors: Dehshahri, Ali
Biagioni, Alessio
Bayat, Hadi
Lee, E. Hui Clarissa 
Hashemabadi, Mohammad
Fekri, Hojjat Samareh
Zarrabi, Ali
Mohammadinejad, Reza
Kumar, Alan Prem 
Keywords: Cancer
Gene editing
SOX transcription factors
Stem cells
Issue Date: 20-Oct-2021
Publisher: MDPI
Citation: Dehshahri, Ali, Biagioni, Alessio, Bayat, Hadi, Lee, E. Hui Clarissa, Hashemabadi, Mohammad, Fekri, Hojjat Samareh, Zarrabi, Ali, Mohammadinejad, Reza, Kumar, Alan Prem (2021-10-20). Editing SOX genes by CRISPR-cas: Current insights and future perspectives. International Journal of Molecular Sciences 22 (21) : 11321. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a substantial revolution has arisen in the genome engineering field. In recent years, CRISPR-Cas technology was rapidly developed and different types of DNA or RNA sequence editors, gene activator or repressor, and epigenome modulators established. The versatility and feasibility of CRISPR-Cas technology has introduced this system as the most suitable tool for discovering and studying the mechanism of specific genes and also for generating appropriate cell and animal models. SOX genes play crucial roles in development processes and stemness. To elucidate the exact roles of SOX factors and their partners in tissue hemostasis and cell regener-ation, generating appropriate in vitro and in vivo models is crucial. In line with these premises, CRISPR-Cas technology is a promising tool for studying different family members of SOX transcription factors. In this review, we aim to highlight the importance of CRISPR-Cas and summarize the applications of this novel, promising technology in studying and decoding the function of different members of the SOX gene family. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
ISSN: 1661-6596
DOI: 10.3390/ijms222111321
Rights: Attribution 4.0 International
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