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Title: ABO genotypes and the risk of esophageal and gastric cancers
Authors: Chen, Yingxi
Hu, Nan
Liao, Linda
Yu, Kai
Shu, Xiao-Ou
Zheng, Wei
Yuan, Jian-Min
Koh, Woon-Puay 
Qiao, You-Lin
Fan, Jin-Hu
Dawsey, Sanford M.
Freedman, Neal D.
Taylor, Philip R.
Goldstein, Alisa M.
Abnet, Christian C.
Keywords: ABO blood type
Esophageal squamous cell carcinoma
Gastric cancer
Issue Date: 22-May-2021
Publisher: BioMed Central Ltd
Citation: Chen, Yingxi, Hu, Nan, Liao, Linda, Yu, Kai, Shu, Xiao-Ou, Zheng, Wei, Yuan, Jian-Min, Koh, Woon-Puay, Qiao, You-Lin, Fan, Jin-Hu, Dawsey, Sanford M., Freedman, Neal D., Taylor, Philip R., Goldstein, Alisa M., Abnet, Christian C. (2021-05-22). ABO genotypes and the risk of esophageal and gastric cancers. BMC Cancer 21 (1) : 589. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Blood type has been associated with the risk of gastric cancer, but few studies have examined the association with esophageal squamous cell carcinoma (ESCC). Methods: We conducted a case-control study using genotyping data of Chinese individuals, including cases of 2022 ESCC, 1189 gastric cardia adenocarcinoma, 1161 gastric noncardia adenocarcinoma, and 2696 controls. Genetic blood type was imputed using three single nucleotide polymorphisms. We used logistic regression to examine the association between blood type and the risk of each cancer. Results: Compared to blood type O, the risk of ESCC was significantly elevated for blood type B and AB, with the highest risk for type AB (OR, 95%CI: 1.34, 1.07–1.67). Analysis of genotype suggested that the association of ESCC was from carrying the B allele. Similarly, blood type was significantly associated with gastric noncardia adenocarcinoma (P < 0.001) with risk significantly elevated in type A (1.37, 1.14–1.65) and AB (1.44, 1.10–1.89) compared to type O. Blood type was not associated with gastric cardia adenocarcinoma (P = 0.13). Conclusions: This study provides novel insights into the association between blood type and the risk of ESCC and restricted previously observed association to only gastric noncardia cancer, providing important evidence to clarify the pattern of association and suggesting mechanisms of action. © 2021, The Author(s).
Source Title: BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-021-08334-1
Rights: Attribution 4.0 International
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