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Title: Mapping the PHQ-8 to EQ-5D, HUI3 and SF6D in patients with depression
Authors: Abdin, Edimansyah
Chong, Siow Ann
Seow, Esmond
Tan, Kelvin Bryan
Subramaniam, Mythily 
Issue Date: 13-Sep-2021
Publisher: BioMed Central Ltd
Citation: Abdin, Edimansyah, Chong, Siow Ann, Seow, Esmond, Tan, Kelvin Bryan, Subramaniam, Mythily (2021-09-13). Mapping the PHQ-8 to EQ-5D, HUI3 and SF6D in patients with depression. BMC Psychiatry 21 (1) : 451. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: There is limited evidence of mapping clinical instruments to a generic preference-based instrument in Asian patient populations. The current study aims to map the eight-item Patient Health Questionnaire depression scale (PHQ-8) onto the EuroQol Five-Dimension (EQ-5D), the Health Utilities Index Mark 3 (HUI3) and the Short Form Six-Dimension (SF-6D) which helps to inform future cost-utility analyses of treatments for depression. Methods: A total of 249 participants who had completed PHQ-8, EQ-5D, SF-6D and HUI3 questionnaires were included in the analyses. A beta regression mixture model was used to map the utility scores as a function of PHQ-8 total scores, PHQ-squared, age and gender. The predictive accuracy of the models was examined using mean absolute error and root mean square error. Results: The results were compared against two common regression methods including Ordinary Least Square (OLS) and Tobit regression models. The mean age of the sample was 36.2 years (SD = 11.1). The mean EQ-5D-3L, EQ-5D-5L, HUI3 and SF-6D utility scores were 0.615, 0.709, 0.461 and 0.607, respectively. The EQ-5D-3L, EQ-5D-5L and SF-6D utility scores were best predicted by the beta mixture regression model consisting of PHQ-8 total sores, PHQ-squared, and covariates including age and gender. The HUI3 was best predicted by the OLS regression model. Conclusions: The current study provides important evidence to clinicians and researchers about the mapping algorithms that can be used in economic evaluation among patients with depression. © 2021, The Author(s).
Source Title: BMC Psychiatry
ISSN: 1471-244X
DOI: 10.1186/s12888-021-03463-0
Rights: Attribution 4.0 International
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