Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-021-26004-5
Title: Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements
Authors: Humphrey, Suzanne
Fillol-Salom, Alfred
Quiles-Puchalt, Nuria
Ibarra-Chávez, Rodrigo
Haag, Andreas F.
Chen, John 
Penadés, José R.
Issue Date: 8-Nov-2021
Publisher: Nature Research
Citation: Humphrey, Suzanne, Fillol-Salom, Alfred, Quiles-Puchalt, Nuria, Ibarra-Chávez, Rodrigo, Haag, Andreas F., Chen, John, Penadés, José R. (2021-11-08). Bacterial chromosomal mobility via lateral transduction exceeds that of classical mobile genetic elements. Nature Communications 12 (1) : 6509. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-021-26004-5
Rights: Attribution 4.0 International
Abstract: It is commonly assumed that the horizontal transfer of most bacterial chromosomal genes is limited, in contrast to the frequent transfer observed for typical mobile genetic elements. However, this view has been recently challenged by the discovery of lateral transduction in Staphylococcus aureus, where temperate phages can drive the transfer of large chromosomal regions at extremely high frequencies. Here, we analyse previously published as well as new datasets to compare horizontal gene transfer rates mediated by different mechanisms in S. aureus and Salmonella enterica. We find that the horizontal transfer of core chromosomal genes via lateral transduction can be more efficient than the transfer of classical mobile genetic elements via conjugation or generalized transduction. These results raise questions about our definition of mobile genetic elements, and the potential roles played by lateral transduction in bacterial evolution. © 2021, The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/232698
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26004-5
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41467-021-26004-5.pdf1.15 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

19
checked on Nov 29, 2022

Page view(s)

8
checked on Dec 1, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons