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Title: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
Authors: Opel, Nils
Thalamuthu, Anbupalam
Milaneschi, Yuri
Grotegerd, Dominik
Flint, Claas
Leenings, Ramona
Goltermann, Janik
Richter, Maike
Hahn, Tim
Woditsch, Georg
Berger, Klaus
Hermesdorf, Marco
McIntosh, Andrew
Whalley, Heather C.
Harris, Mathew A.
MacMaster, Frank P.
Walter, Henrik
Veer, Ilya M.
Frodl, Thomas
Carballedo, Angela
Krug, Axel
Nenadic, Igor
Kircher, Tilo
Aleman, Andre
Groenewold, Nynke A.
Stein, Dan J.
Soares, Jair C.
Zunta-Soares, Giovana B.
Mwangi, Benson
Wu, Mon-Ju
Walter, Martin
Li, Meng
Harrison, Ben J.
Davey, Christopher G.
Cullen, Kathryn R.
Klimes-Dougan, Bonnie
Mueller, Bryon A.
Sämann, P.G.
Penninx, Brenda
Nawijn, Laura
Veltman, Dick J.
Aftanas, Lyubomir
Brak, Ivan, V
Filimonova, Elena A.
Osipov, Evgeniy A.
Reneman, Liesbeth
Schrantee, Anouk
Grabe, Hans J.
Van der Auwera, Sandra
Wittfeld, Katharina
Hosten, Norbert
Völzke, H.
Sim, Kang 
Gotlib, Ian H.
Sacchet, Matthew D.
Lagopoulos, Jim
Hatton, Sean N.
Hickie, Ian
Pozzi, Elena
Thompson, Paul M.
Jahanshad, Neda
Schmaal, Lianne
Baune, Bernhard T.
Dannlowski, Udo
Issue Date: 28-May-2020
Publisher: Springer Nature
Citation: Opel, Nils, Thalamuthu, Anbupalam, Milaneschi, Yuri, Grotegerd, Dominik, Flint, Claas, Leenings, Ramona, Goltermann, Janik, Richter, Maike, Hahn, Tim, Woditsch, Georg, Berger, Klaus, Hermesdorf, Marco, McIntosh, Andrew, Whalley, Heather C., Harris, Mathew A., MacMaster, Frank P., Walter, Henrik, Veer, Ilya M., Frodl, Thomas, Carballedo, Angela, Krug, Axel, Nenadic, Igor, Kircher, Tilo, Aleman, Andre, Groenewold, Nynke A., Stein, Dan J., Soares, Jair C., Zunta-Soares, Giovana B., Mwangi, Benson, Wu, Mon-Ju, Walter, Martin, Li, Meng, Harrison, Ben J., Davey, Christopher G., Cullen, Kathryn R., Klimes-Dougan, Bonnie, Mueller, Bryon A., Sämann, P.G., Penninx, Brenda, Nawijn, Laura, Veltman, Dick J., Aftanas, Lyubomir, Brak, Ivan, V, Filimonova, Elena A., Osipov, Evgeniy A., Reneman, Liesbeth, Schrantee, Anouk, Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Hosten, Norbert, Völzke, H., Sim, Kang, Gotlib, Ian H., Sacchet, Matthew D., Lagopoulos, Jim, Hatton, Sean N., Hickie, Ian, Pozzi, Elena, Thompson, Paul M., Jahanshad, Neda, Schmaal, Lianne, Baune, Bernhard T., Dannlowski, Udo (2020-05-28). Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group. Molecular Psychiatry 26 (9) : 4839-4852. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = ?0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions. © 2020, The Author(s).
Source Title: Molecular Psychiatry
ISSN: 1359-4184
DOI: 10.1038/s41380-020-0774-9
Rights: Attribution 4.0 International
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