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Title: The cardiac nanoenvironment: form and function at the nanoscale
Authors: Jashan Preet Singh
Jennifer Lauren Young 
Keywords: Cardiomyocyte
Extracellular matrix
Issue Date: 31-Aug-2021
Publisher: Springer Science and Business Media Deutschland GmbH
Citation: Jashan Preet Singh, Jennifer Lauren Young (2021-08-31). The cardiac nanoenvironment: form and function at the nanoscale. Biophysical Reviews 13 (5) : 625-636. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Mechanical forces in the cardiovascular system occur over a wide range of length scales. At the whole organ level, large scale forces drive the beating heart as a synergistic unit. On the microscale, individual cells and their surrounding extracellular matrix (ECM) exhibit dynamic reciprocity, with mechanical feedback moving bidirectionally. Finally, in the nanometer regime, molecular features of cells and the ECM show remarkable sensitivity to mechanical cues. While small, these nanoscale properties are in many cases directly responsible for the mechanosensitive signaling processes that elicit cellular outcomes. Given the inherent challenges in observing, quantifying, and reconstituting this nanoscale environment, it is not surprising that this landscape has been understudied compared to larger length scales. Here, we aim to shine light upon the cardiac nanoenvironment, which plays a crucial role in maintaining physiological homeostasis while also underlying pathological processes. Thus, we will highlight strategies aimed at (1) elucidating the nanoscale components of the cardiac matrix, and (2) designing new materials and biosystems capable of mimicking these features in vitro. © 2021, The Author(s).
Source Title: Biophysical Reviews
ISSN: 1867-2450
DOI: 10.1007/s12551-021-00834-5
Rights: Attribution 4.0 International
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