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Title: Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy
Authors: Mohammad Tavakkoli Yaraki
Wu, Min 
Middha, Eshu
Wu, Wenbo 
Soroosh Daqiqeh Rezaei
Liu, Bin 
Tan, Yen Nee
Keywords: Aggregation-induced emission
Fluorescence imaging
Plasmon enhancement
Issue Date: 1-Jan-2021
Publisher: Springer Science and Business Media B.V.
Citation: Mohammad Tavakkoli Yaraki, Wu, Min, Middha, Eshu, Wu, Wenbo, Soroosh Daqiqeh Rezaei, Liu, Bin, Tan, Yen Nee (2021-01-01). Gold Nanostars-AIE Theranostic Nanodots with Enhanced Fluorescence and Photosensitization Towards Effective Image-Guided Photodynamic Therapy. Nano-Micro Letters 13 (1) : 58. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Dual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1O2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1O2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy. [Figure not available: see fulltext.] © 2021, The Author(s).
Source Title: Nano-Micro Letters
ISSN: 2311-6706
DOI: 10.1007/s40820-020-00583-2
Rights: Attribution 4.0 International
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