Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom11020304
Title: Small in size, but large in action: Micrornas as potential modulators of pten in breast and lung cancers
Authors: Abadi, Asal Jalal
Zarrabi, Ali
Gholami, Mohammad Hossein
Mirzaei, Sepideh
Hashemi, Farid
Zabolian, Amirhossein
Entezari, Maliheh
Hushmandi, Kiavash
Ashrafizadeh, Milad
Khan, Haroon
Kumar, Alan Prem 
Keywords: Breast cancer
Cancer therapy
Circular RNA
Long non?coding RNA
Lung cancer
MicroRNA
PTEN
Issue Date: 18-Feb-2021
Publisher: MDPI AG
Citation: Abadi, Asal Jalal, Zarrabi, Ali, Gholami, Mohammad Hossein, Mirzaei, Sepideh, Hashemi, Farid, Zabolian, Amirhossein, Entezari, Maliheh, Hushmandi, Kiavash, Ashrafizadeh, Milad, Khan, Haroon, Kumar, Alan Prem (2021-02-18). Small in size, but large in action: Micrornas as potential modulators of pten in breast and lung cancers. Biomolecules 11 (2) : Jan-36. ScholarBank@NUS Repository. https://doi.org/10.3390/biom11020304
Rights: Attribution 4.0 International
Abstract: MicroRNAs (miRNAs) are well?known regulators of biological mechanisms with a small size of 19–24 nucleotides and a single?stranded structure. miRNA dysregulation occurs in cancer progression. miRNAs can function as tumor?suppressing or tumor?promoting factors in cancer via regulating molecular pathways. Breast and lung cancers are two malignant thoracic tumors in which the abnormal expression of miRNAs plays a significant role in their development. Phospha-tase and tensin homolog (PTEN) is a tumor?suppressor factor that is capable of suppressing the growth, viability, and metastasis of cancer cells via downregulating phosphatidylinositol 3?kinase (PI3K)/protein kinase B (Akt) signaling. PTEN downregulation occurs in lung and breast cancers to promote PI3K/Akt expression, leading to uncontrolled proliferation, metastasis, and their resistance to chemotherapy and radiotherapy. miRNAs as upstream mediators of PTEN can dually induce/in-hibit PTEN signaling in affecting the malignant behavior of lung and breast cancer cells. Further-more, long non?coding RNAs and circular RNAs can regulate the miRNA/PTEN axis in lung and breast cancer cells. It seems that anti?tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression. These topics are discussed in the current review with a focus on molecular pathways. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Biomolecules
URI: https://scholarbank.nus.edu.sg/handle/10635/232524
ISSN: 2218-273X
DOI: 10.3390/biom11020304
Rights: Attribution 4.0 International
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