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Title: Anti-inflammatory and anticancer properties of birch bark-derived betulin: Recent developments
Authors: Tuli, Hardeep Singh
Sak, Katrin
Gupta, Dhruv Sanjay
Kaur, Ginpreet
Aggarwal, Diwakar
Chaturvedi Parashar, Nidarshana
Choudhary, Renuka
Yerer, Mukerrem Betul
Kaur, Jagjit
Kumar, Manoj
Garg, Vivek Kumar
Sethi, Gautam 
Keywords: Betulin
Birch bark
Issue Date: 3-Dec-2021
Publisher: MDPI
Citation: Tuli, Hardeep Singh, Sak, Katrin, Gupta, Dhruv Sanjay, Kaur, Ginpreet, Aggarwal, Diwakar, Chaturvedi Parashar, Nidarshana, Choudhary, Renuka, Yerer, Mukerrem Betul, Kaur, Jagjit, Kumar, Manoj, Garg, Vivek Kumar, Sethi, Gautam (2021-12-03). Anti-inflammatory and anticancer properties of birch bark-derived betulin: Recent developments. Plants 10 (12) : 2663. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Birch tree bark-derived betulin has attracted scientific interest already for several centuries, being one of the first natural products identified from plants. However, the cellular events regulated by betulin and precise molecular mechanisms under these processes have been begun to be understood only recently. Today, we know that betulin can exert important anticancer activities through modulation of diverse cellular pathways. In this review article, betulin-regulated molecular signaling is unraveled and presented with a special focus on its participation in anti-inflammatory processes, especially by modulating nuclear factor-?B (NF-?B), prostaglandin/COX, and nuclear factor erythroid2-related factor 2 (Nrf2)-mediated cascades. By regulating these diverse pathways, betulin can not only affect the development and progression of different cancers, but also enhance the antitumor action of traditional therapeutic modalities. It is expected that by overcoming the low bioavailability of betulin by encapsulating it into nanocarriers, this promising natural compound may provide novel possibilities for targeting inflammation-related cancers. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Plants
ISSN: 2223-7747
DOI: 10.3390/plants10122663
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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