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Title: Disease prevalence matters: Challenge for SARS-CoV-2 testing
Authors: Lau, Chin-Shern
Aw, Tar-Choon 
Keywords: Disease prevalence
Orthogonal testing
Issue Date: 17-Dec-2021
Publisher: MDPI
Citation: Lau, Chin-Shern, Aw, Tar-Choon (2021-12-17). Disease prevalence matters: Challenge for SARS-CoV-2 testing. Antibodies 10 (4) : 50. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: While sensitivity and specificity are important characteristics for any diagnostic test, the influence of prevalence is equally, if not more, important when such tests are used in community screening. We review the concepts of positive/negative predictive values (PPV/NPV) and how disease prevalence affects false positive/negative rates. In low-prevalence situations, the PPV decreases drastically. We demonstrate how using two tests in an orthogonal fashion can be especially beneficial in low-prevalence settings and greatly improve the PPV of the diagnostic test results. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antibodies
ISSN: 2073-4468
DOI: 10.3390/antib10040050
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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