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Title: ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer
Authors: Neyrinck-Leglantier, Deborah
Lesage, Julien
Blacher, Silvia
Bonnomet, Arnaud
Hunziker, Walter 
Noël, Agnès
Dormoy, Valerian
Nawrocki-Raby, Beatrice
Gilles, Christine
Polette, Myriam
Keywords: epithelial plasticity
epithelial-mesenchymal transition
immune infiltrate
lung cancer
tumor microenvironment
Issue Date: 6-Dec-2021
Publisher: Frontiers Media S.A.
Citation: Neyrinck-Leglantier, Deborah, Lesage, Julien, Blacher, Silvia, Bonnomet, Arnaud, Hunziker, Walter, Noël, Agnès, Dormoy, Valerian, Nawrocki-Raby, Beatrice, Gilles, Christine, Polette, Myriam (2021-12-06). ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology 9 : 749364. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression. Copyright © 2021 Neyrinck-Leglantier, Lesage, Blacher, Bonnomet, Hunziker, Noël, Dormoy, Nawrocki-Raby, Gilles and Polette.
Source Title: Frontiers in Cell and Developmental Biology
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.749364
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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