ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer
Neyrinck-Leglantier, Deborah Lesage, Julien Blacher, Silvia Bonnomet, Arnaud Hunziker, Walter Noël, Agnès Dormoy, Valerian Nawrocki-Raby, Beatrice Gilles, Christine Polette, Myriam
Neyrinck-Leglantier, Deborah
Lesage, Julien
Blacher, Silvia
Bonnomet, Arnaud
Noël, Agnès
Dormoy, Valerian
Nawrocki-Raby, Beatrice
Gilles, Christine
Polette, Myriam
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Alternative Title
Abstract
Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression. Copyright © 2021 Neyrinck-Leglantier, Lesage, Blacher, Bonnomet, Hunziker, Noël, Dormoy, Nawrocki-Raby, Gilles and Polette.
Keywords
epithelial plasticity, epithelial-mesenchymal transition, immune infiltrate, lung cancer, tumor microenvironment, ZO-1
Source Title
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media S.A.
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2021-12-06
DOI
10.3389/fcell.2021.749364
Type
Article