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Title: Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm
Authors: Paalanne, Marika
Vääräsmäki, M.
Mustaniemi, Sanna
Tikanmäki, M.
Wehkalampi, Karoliina
Maria Matinolli, H.
Eriksson, Johan 
Järvelin, M.-R.
Morin-Papunen, Laure
Kajantie, Eero
Issue Date: 1-Aug-2021
Publisher: BioScientifica Ltd.
Citation: Paalanne, Marika, Vääräsmäki, M., Mustaniemi, Sanna, Tikanmäki, M., Wehkalampi, Karoliina, Maria Matinolli, H., Eriksson, Johan, Järvelin, M.-R., Morin-Papunen, Laure, Kajantie, Eero (2021-08-01). Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm. European Journal of Endocrinology 185 (2) : 279-288. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Objective: It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term. Design: The ESTER Preterm Birth Study participants were born in Norther n Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34-36 weeks, LPT), and 184 born full term (?37 weeks, controls) were included in the analysis (mean age: 23.2 years). Methods: We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and bioche mical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L). Results: Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (-2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject's birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70). Conclusions: Women born preterm have a more hyperandrogenic hormonal profil e, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term. © 2021 BioScientifica Ltd.. All rights reserved.
Source Title: European Journal of Endocrinology
ISSN: 0804-4643
DOI: 10.1530/eje-20-1462
Rights: Attribution 4.0 International
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