Please use this identifier to cite or link to this item: https://doi.org/10.1042/bcj20210412
Title: Meiosis initiation: A story of two sexes in all creatures great and small
Authors: Sou, Ieng Fong
Pryce, Rebecca M.
Tee, Wee-Wei 
McClurg, Urszula Lucja
Issue Date: 28-Oct-2021
Publisher: Portland Press Ltd
Citation: Sou, Ieng Fong, Pryce, Rebecca M., Tee, Wee-Wei, McClurg, Urszula Lucja (2021-10-28). Meiosis initiation: A story of two sexes in all creatures great and small. Biochemical Journal 478 (20) : 3791-3805. ScholarBank@NUS Repository. https://doi.org/10.1042/bcj20210412
Rights: Attribution 4.0 International
Abstract: Meiosis facilitates diversity across individuals and serves as a major driver of evolution. However, understanding how meiosis begins is complicated by fundamental differences that exist between sexes and species. Fundamental meiotic research is further hampered by a current lack of human meiotic cells lines. Consequently, much of what we know relies on data from model organisms. However, contextualising findings from yeast, worms, flies and mice can be challenging, due to marked differences in both nomenclature and the relative timing of meiosis. In this review, we set out to combine current knowledge of signalling and transcriptional pathways that control meiosis initiation across the sexes in a variety of organisms. Furthermore, we highlight the emerging links between meiosis initiation and oncogenesis, which might explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers. © 2021 Portland Press Ltd. All rights reserved.
Source Title: Biochemical Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/232204
ISSN: 0264-6021
DOI: 10.1042/bcj20210412
Rights: Attribution 4.0 International
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