Please use this identifier to cite or link to this item:
Title: Meiosis initiation: A story of two sexes in all creatures great and small
Authors: Sou, Ieng Fong
Pryce, Rebecca M.
Tee, Wee-Wei 
McClurg, Urszula Lucja
Issue Date: 28-Oct-2021
Publisher: Portland Press Ltd
Citation: Sou, Ieng Fong, Pryce, Rebecca M., Tee, Wee-Wei, McClurg, Urszula Lucja (2021-10-28). Meiosis initiation: A story of two sexes in all creatures great and small. Biochemical Journal 478 (20) : 3791-3805. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Meiosis facilitates diversity across individuals and serves as a major driver of evolution. However, understanding how meiosis begins is complicated by fundamental differences that exist between sexes and species. Fundamental meiotic research is further hampered by a current lack of human meiotic cells lines. Consequently, much of what we know relies on data from model organisms. However, contextualising findings from yeast, worms, flies and mice can be challenging, due to marked differences in both nomenclature and the relative timing of meiosis. In this review, we set out to combine current knowledge of signalling and transcriptional pathways that control meiosis initiation across the sexes in a variety of organisms. Furthermore, we highlight the emerging links between meiosis initiation and oncogenesis, which might explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers. © 2021 Portland Press Ltd. All rights reserved.
Source Title: Biochemical Journal
ISSN: 0264-6021
DOI: 10.1042/bcj20210412
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1042_bcj20210412.pdf1.63 MBAdobe PDF




checked on Nov 29, 2022

Page view(s)

checked on Dec 1, 2022

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons