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Title: Shifting the gears of metabolic plasticity to drive cell state transitions in cancer
Authors: Wu, Zhengwei
Lee, Yi Fei
Yeo, Xun Hui
Loo, Ser Yue
Tam, Wai Leong 
Keywords: Cancer stem cells
Cell state transition
Cellular plasticity
Epithelial–mesenchymal transition
Phenotype switching
Therapy resistance
Issue Date: 15-Mar-2021
Publisher: MDPI AG
Citation: Wu, Zhengwei, Lee, Yi Fei, Yeo, Xun Hui, Loo, Ser Yue, Tam, Wai Leong (2021-03-15). Shifting the gears of metabolic plasticity to drive cell state transitions in cancer. Cancers 13 (6) : Jan-22. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Cancer metabolism is a hallmark of cancer. Metabolic plasticity defines the ability of cancer cells to reprogram a plethora of metabolic pathways to meet unique energetic needs during the various steps of disease progression. Cell state transitions are phenotypic adaptations which confer distinct advantages that help cancer cells overcome progression hurdles, that include tumor initiation, expansive growth, resistance to therapy, metastasis, colonization, and relapse. It is in-creasingly appreciated that cancer cells need to appropriately reprogram their cellular metabolism in a timely manner to support the changes associated with new phenotypic cell states. We discuss metabolic alterations that may be adopted by cancer cells in relation to the maintenance of cancer stemness, activation of the epithelial–mesenchymal transition program for facilitating metastasis, and the acquisition of drug resistance. While such metabolic plasticity is harnessed by cancer cells for survival, their dependence and addiction towards certain metabolic pathways also present therapeutic opportunities that may be exploited. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Cancers
ISSN: 2072-6694
DOI: 10.3390/cancers13061316
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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