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Title: Enhanced virulence of Plasmodium falciparum in blood of diabetic patients
Authors: Ch'ng, Jun-Hong 
Moll, Kirsten
Wyss, Katja
Hammar, Ulf
Rydén, Mikael
Kämpe, Olle
Färnert, Anna
Wahlgren, Mats
Issue Date: 17-Jun-2021
Publisher: Public Library of Science
Citation: Ch'ng, Jun-Hong, Moll, Kirsten, Wyss, Katja, Hammar, Ulf, Rydén, Mikael, Kämpe, Olle, Färnert, Anna, Wahlgren, Mats (2021-06-17). Enhanced virulence of Plasmodium falciparum in blood of diabetic patients. PLoS ONE 16 (6-Jun) : e0249666. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Rising prevalence of diabetes in sub-Saharan Africa, coupled with continued malaria transmission, has resulted more patients dealing with both communicable and non-communicable diseases. We previously reported that travelers with type 2 diabetes mellitus (T2DM) infected with Plasmodium falciparum were three times more likely to develop severe malaria than non-diabetics. Here we explore the biological basis for this by testing blood from uninfected subjects with type 1 and type 2 diabetes, ex vivo, for their effects on parasite growth and rosetting (binding of infected erythrocytes to uninfected erythrocytes). Rosetting was associated with type 2 diabetes, blood glucose and erythrocyte sedimentation rate (ESR), while parasite growth was positively associated with blood glucose, glycated hemoglobin (HbA1c), body mass index (BMI), fibrinogen and triglycerides. This study establishes a link between diabetes and malaria virulence assays, potentially explaining the protective effect of good glycemic control against severe malaria in subjects with diabetes. © 2021 Ch'ng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0249666
Rights: Attribution 4.0 International
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