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Title: From jekyll to hyde: The yeast–hyphal transition of Candida albicans
Authors: Chow, Eve Wai Ling
Pang, Li Mei
Wang, Yue 
Keywords: Cell cycle regulation
Hyphal activation
Hyphal morphogenesis
Signal transduction pathways
Issue Date: 7-Jul-2021
Publisher: MDPI
Citation: Chow, Eve Wai Ling, Pang, Li Mei, Wang, Yue (2021-07-07). From jekyll to hyde: The yeast–hyphal transition of Candida albicans. Pathogens 10 (7) : 859. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Candida albicans is a major fungal pathogen of humans, accounting for 15% of nosocomial infections with an estimated attributable mortality of 47%. C. albicans is usually a benign member of the human microbiome in healthy people. Under constant exposure to highly dynamic environmental cues in diverse host niches, C. albicans has successfully evolved to adapt to both commensal and pathogenic lifestyles. The ability of C. albicans to undergo a reversible morphological transition from yeast to filamentous forms is a well-established virulent trait. Over the past few decades, a significant amount of research has been carried out to understand the underlying regulatory mechanisms, signaling pathways, and transcription factors that govern the C. albicans yeast-to-hyphal transition. This review will summarize our current understanding of well-elucidated signal transduction pathways that activate C. albicans hyphal morphogenesis in response to various environmental cues and the cell cycle machinery involved in the subsequent regulation and maintenance of hyphal morphogenesis. © 2021 by the authors.
Source Title: Pathogens
ISSN: 2076-0817
DOI: 10.3390/pathogens10070859
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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