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Title: Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies
Authors: Li, Wenlong
Thian, Eng San 
Wang, Miao
Wang, Zuyong
Ren, Lei
Keywords: antibacterial materials
bacterial targeting
clinical infection
surface modification
Issue Date: 5-Aug-2021
Publisher: John Wiley and Sons Inc
Citation: Li, Wenlong, Thian, Eng San, Wang, Miao, Wang, Zuyong, Ren, Lei (2021-08-05). Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies. Advanced Science 8 (19) : 2100368. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Healthcare-acquired infections as well as increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene have attracted great interest, in particular, the emergence of surface design strategies offer an effective alternative to antibiotics, thereby preventing the possible development of bacterial resistance. In this review, recent progress on advanced surface modifications to prevent bacterial infections are addressed comprehensively, starting with the key factors against bacterial adhesion, followed by varying strategies that can inhibit biofilm formation effectively. Furthermore, “super antibacterial systems” through pre-treatment defense and targeted bactericidal system, are proposed with increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies to resist healthcare-associated infections are discussed, with promising prospects of developing novel antimicrobial materials. © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH
Source Title: Advanced Science
ISSN: 2198-3844
DOI: 10.1002/advs.202100368
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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