Please use this identifier to cite or link to this item: https://doi.org/10.3389/fphar.2021.651884
Title: An Updated Insight Into Molecular Mechanism of Hydrogen Sulfide in Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury Under Diabetes
Authors: Sun, Hai-Jian 
Wu, Zhi-Yuan 
Nie, Xiao-Wei 
Wang, Xin-Yu
Bian, Jin-Song 
Keywords: diabetes
diabetic cardiomyopathy
hydrogen sulfide
ischaemia-reperfusion injury
nitric oxide
Issue Date: 26-Oct-2021
Publisher: Frontiers Media S.A.
Citation: Sun, Hai-Jian, Wu, Zhi-Yuan, Nie, Xiao-Wei, Wang, Xin-Yu, Bian, Jin-Song (2021-10-26). An Updated Insight Into Molecular Mechanism of Hydrogen Sulfide in Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury Under Diabetes. Frontiers in Pharmacology 12 : 651884. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2021.651884
Rights: Attribution 4.0 International
Abstract: Cardiovascular diseases are the most common complications of diabetes, and diabetic cardiomyopathy is a major cause of people death in diabetes. Molecular, transcriptional, animal, and clinical studies have discovered numerous therapeutic targets or drugs for diabetic cardiomyopathy. Within this, hydrogen sulfide (H2S), an endogenous gasotransmitter alongside with nitric oxide (NO) and carbon monoxide (CO), is found to play a critical role in diabetic cardiomyopathy. Recently, the protective roles of H2S in diabetic cardiomyopathy have attracted enormous attention. In addition, H2S donors confer favorable effects in myocardial infarction, ischaemia-reperfusion injury, and heart failure under diabetic conditions. Further studies have disclosed that multiplex molecular mechanisms are responsible for the protective effects of H2S against diabetes-elicited cardiac injury, such as anti-oxidative, anti-apoptotic, anti-inflammatory, and anti-necrotic properties. In this review, we will summarize the current findings on H2S biology and pharmacology, especially focusing on the novel mechanisms of H2S-based protection against diabetic cardiomyopathy. Also, the potential roles of H2S in diabetes-aggravated ischaemia-reperfusion injury are discussed. Copyright © 2021 Sun, Wu, Nie, Wang and Bian.
Source Title: Frontiers in Pharmacology
URI: https://scholarbank.nus.edu.sg/handle/10635/232004
ISSN: 1663-9812
DOI: 10.3389/fphar.2021.651884
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3389_fphar_2021_651884.pdf2.22 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons