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Title: A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
Authors: Tan, Chew Teng
Xu, Xiaoli
Qiao, Yuan
Wang, Yue 
Issue Date: 7-May-2021
Publisher: Nature Research
Citation: Tan, Chew Teng, Xu, Xiaoli, Qiao, Yuan, Wang, Yue (2021-05-07). A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection. Nature Communications 12 (1) : 2560. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of C. albicans. We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive Staphylococcus aureus. Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining C. albicans in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for C. albicans infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence. © 2021, The Author(s).
Source Title: Nature Communications
ISSN: 2041-1723
DOI: 10.1038/s41467-021-22845-2
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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