Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12951-021-01168-w
Title: | NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors | Authors: | Jia, Ruizhen Xu, Han Wang, Chenlu Su, Lichao Jing, Jinpeng Xu, Shuyu Zhou, Yu Sun, Wenjing Song, Jibin Chen, Xiaoyuan Chen, Hongmin |
Keywords: | AIE Imaging-guided surgery NIR-II imaging Orthotopic hepatic tumors Phototherapy |
Issue Date: | 1-Dec-2021 | Publisher: | BioMed Central Ltd | Citation: | Jia, Ruizhen, Xu, Han, Wang, Chenlu, Su, Lichao, Jing, Jinpeng, Xu, Shuyu, Zhou, Yu, Sun, Wenjing, Song, Jibin, Chen, Xiaoyuan, Chen, Hongmin (2021-12-01). NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors. Journal of Nanobiotechnology 19 (1) : 419. ScholarBank@NUS Repository. https://doi.org/10.1186/s12951-021-01168-w | Rights: | Attribution 4.0 International | Abstract: | Accurate diagnosis and effective treatment of primary liver tumors are of great significance, and optical imaging has been widely employed in clinical imaging-guided surgery for liver tumors. The second near-infrared window (NIR-II) emissive AIEgen photosensitizers have attracted a lot of attention with higher-resolution bioimaging and deeper penetration. NIR-II aggregation-induced emission-based luminogen (AIEgen) photosensitizers have better phototherapeutic effects and accuracy of the image-guided surgery/phototherapy. Herein, an NIR-II AIEgen phototheranostic dot was proposed for NIR-II imaging-guided resection surgery and phototherapy for orthotopic hepatic tumors. Compared with indocyanine green (ICG), the AIEgen dots showed bright and sharp NIR-II emission at 1250 nm, which extended to 1600 nm with high photostability. Moreover, the AIEgen dots efficiently generated reactive oxygen species (ROS) for photodynamic therapy. Investigations of orthotopic liver tumors in vitro and in vivo demonstrated that AIEgen dots could be employed both for imaging-guided tumor surgery of early-stage tumors and for ‘downstaging’ intention to reduce the size. Moreover, the therapeutic strategy induced complete inhibition of orthotopic tumors without recurrence and with few side effects. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s). | Source Title: | Journal of Nanobiotechnology | URI: | https://scholarbank.nus.edu.sg/handle/10635/231892 | ISSN: | 1477-3155 | DOI: | 10.1186/s12951-021-01168-w | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1186_s12951-021-01168-w.pdf | 1.93 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License