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Title: NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors
Authors: Jia, Ruizhen
Xu, Han
Wang, Chenlu
Su, Lichao
Jing, Jinpeng
Xu, Shuyu
Zhou, Yu
Sun, Wenjing
Song, Jibin
Chen, Xiaoyuan 
Chen, Hongmin
Keywords: AIE
Imaging-guided surgery
NIR-II imaging
Orthotopic hepatic tumors
Issue Date: 1-Dec-2021
Publisher: BioMed Central Ltd
Citation: Jia, Ruizhen, Xu, Han, Wang, Chenlu, Su, Lichao, Jing, Jinpeng, Xu, Shuyu, Zhou, Yu, Sun, Wenjing, Song, Jibin, Chen, Xiaoyuan, Chen, Hongmin (2021-12-01). NIR-II emissive AIEgen photosensitizers enable ultrasensitive imaging-guided surgery and phototherapy to fully inhibit orthotopic hepatic tumors. Journal of Nanobiotechnology 19 (1) : 419. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Accurate diagnosis and effective treatment of primary liver tumors are of great significance, and optical imaging has been widely employed in clinical imaging-guided surgery for liver tumors. The second near-infrared window (NIR-II) emissive AIEgen photosensitizers have attracted a lot of attention with higher-resolution bioimaging and deeper penetration. NIR-II aggregation-induced emission-based luminogen (AIEgen) photosensitizers have better phototherapeutic effects and accuracy of the image-guided surgery/phototherapy. Herein, an NIR-II AIEgen phototheranostic dot was proposed for NIR-II imaging-guided resection surgery and phototherapy for orthotopic hepatic tumors. Compared with indocyanine green (ICG), the AIEgen dots showed bright and sharp NIR-II emission at 1250 nm, which extended to 1600 nm with high photostability. Moreover, the AIEgen dots efficiently generated reactive oxygen species (ROS) for photodynamic therapy. Investigations of orthotopic liver tumors in vitro and in vivo demonstrated that AIEgen dots could be employed both for imaging-guided tumor surgery of early-stage tumors and for ‘downstaging’ intention to reduce the size. Moreover, the therapeutic strategy induced complete inhibition of orthotopic tumors without recurrence and with few side effects. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s).
Source Title: Journal of Nanobiotechnology
ISSN: 1477-3155
DOI: 10.1186/s12951-021-01168-w
Rights: Attribution 4.0 International
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