Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.heliyon.2022.e10131
Title: Evaluation of anthoxanthins and their actions on digestive enzyme inhibition when used independently and in combination
Authors: Koh, YQ 
Sin, YAD
Rong, HJ
Chua, THS
Ho, SHS
Ho, HK 
Keywords: Acarbose
Anthoxanthins
Synergistic inhibition
α-amylase
α-glucosidase
Issue Date: 1-Aug-2022
Publisher: Elsevier BV
Citation: Koh, YQ, Sin, YAD, Rong, HJ, Chua, THS, Ho, SHS, Ho, HK (2022-08-01). Evaluation of anthoxanthins and their actions on digestive enzyme inhibition when used independently and in combination. Heliyon 8 (8) : e10131-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.heliyon.2022.e10131
Abstract: Carbohydrate digestibility is a key determinant for elevated postprandial hyperglycemia (PPHG). Apart from dietary restrictions, one of the strategies to reduce PPHG is to limit the activity of carbohydrate digestive enzymes within the gastrointestinal tract in order to reduce monosaccharide absorption rates. The present work aimed to assess the inhibitory capabilities of digestive enzymes (e.g., α-glucosidase and α-amylase) by anthoxanthins when used independently, in combination with acarbose, or with a different anthoxanthin. Our results showed that quercetin, myricetin, and luteolin presented lower IC50 values than acarbose and inhibited α-glucosidase through mixed-type inhibition. On the other hand, acarbose when compared with these anthoxanthins, remained the most potent inhibitor of α-amylase. Combinatorial treatment (i) acarbose-quercetin and (ii) myricetin-luteolin showed synergistic activity (CI value less than 0.9) in α-glucosidase inhibition. An additive effect (CI value between 0.9 and 1.1) in α-glucosidase inhibition was observed when acarbose-myricetin, acarbose-luteolin or when a combination of two different anthoxanthins (quercetin-myricetin and quercetin-luteolin) was used. This study suggests the potential use of anthoxanthins as functional food ingredients to mitigate PPHG towards the management of T2DM.
Source Title: Heliyon
URI: https://scholarbank.nus.edu.sg/handle/10635/231163
ISSN: 24058440
DOI: 10.1016/j.heliyon.2022.e10131
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