Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.waojou.2022.100667
Title: Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort
Authors: Lau, Hui Xing
Chen, Zhaojin
Chan, Yiong Huak 
Tham, Elizabeth Huiwen 
Goh, Anne Eng Neo 
Van Bever, Hugo 
Teoh, Oon Hoe 
Karnani, Neerja 
Gluckman, Peter D
Tan, Kok Hian 
Yap, Fabian Kok Peng 
Godfrey, Keith M
Eriksson, Johan G
Chong, Yap Seng 
Lee, Bee Wah 
Shek, Lynette Pei-Chi 
Loo, Evelyn Xiu Ling 
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Allergic sensitization trajectories
Latent class analysis
Eczema
Wheeze
House dust mite
LATENT CLASS ANALYSIS
ATOPY PHENOTYPES
DISEASES
BARRIER
ASTHMA
Issue Date: 1-Jul-2022
Publisher: ELSEVIER
Citation: Lau, Hui Xing, Chen, Zhaojin, Chan, Yiong Huak, Tham, Elizabeth Huiwen, Goh, Anne Eng Neo, Van Bever, Hugo, Teoh, Oon Hoe, Karnani, Neerja, Gluckman, Peter D, Tan, Kok Hian, Yap, Fabian Kok Peng, Godfrey, Keith M, Eriksson, Johan G, Chong, Yap Seng, Lee, Bee Wah, Shek, Lynette Pei-Chi, Loo, Evelyn Xiu Ling (2022-07-01). Allergic sensitization trajectories to age 8 years in the Singapore GUSTO cohort. WORLD ALLERGY ORGANIZATION JOURNAL 15 (7). ScholarBank@NUS Repository. https://doi.org/10.1016/j.waojou.2022.100667
Abstract: Background: Allergic sensitization is linked to allergy development, with early sensitization often associated with worse outcomes. We aimed to identify if distinct allergic sensitization trajectories existed within a diverse and multi-ethnic Asian cohort. Methods: We administered modified ISAAC questionnaires in the first 8 years and conducted skin prick testing at ages 18 months, 3, 5 and 8 years in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. We used latent class analysis to derive allergic sensitization trajectories, and adjusted odds ratios (AOR) to evaluate predictive risk factors and associations with allergic comorbidities. Results: Among 997 children, three trajectories were identified: early food and mite sensitization (16.2%), late mite sensitization (24.2%) and no/low sensitization (59.6%). Early food and mite sensitization was associated with early eczema by 6 months [AOR (95%CI) 4.67 (1.78–12.28)], increased risk of wheeze by 3–8 years (ARR 1.72–1.99) and eczema in the first 8 years of life (ARR 1.87–2.41). Late mite sensitization was associated with female sex [AOR 0.58 (0.35–0.96)], cesarean section [AOR 0.54 (0.30–0.98)], early eczema by 6 months [AOR 3.40 (1.38–8.42)], and increased risk of eczema by 18 months [ARR 1.47 (1.03–2.08)] and 8 years [ARR 1.35 (1.05–1.73)]. Conclusion: Early onset of eczema and early allergic sensitization were strongly associated. Early sensitization, especially to house dust mites, was associated with increased risks of developing wheeze and eczema, pointing to the importance of developing preventive perinatal interventions and effective therapeutics for sensitized toddlers.
Source Title: WORLD ALLERGY ORGANIZATION JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/230141
ISSN: 19394551
DOI: 10.1016/j.waojou.2022.100667
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