Please use this identifier to cite or link to this item: https://doi.org/10.1186/s10020-021-00344-w
Title: Placental C-13-DHA metabolism and relationship with maternal BMI, glycemia and birthweight
Authors: Watkins, Oliver C 
Selvam, Preben 
Appukuttan Pillai, Reshma 
Cracknell-Hazra, Victoria KB
Yong, Hannah EJ
Sharma, Neha 
Cazenave-Gassiot, Amaury 
Bendt, Anne K 
Godfrey, Keith M
Lewis, Rohan M
Wenk, Markus R 
Chan, Shiao-Yng
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
Pregnancy
Placenta
Lipid
Stable-isotope
Gestational diabetes
LCMS
GESTATIONAL DIABETES-MELLITUS
POLYUNSATURATED FATTY-ACID
DOCOSAHEXAENOIC ACID
PREGNANT-WOMEN
FETAL TRANSFER
OBESITY
GROWTH
DHA
ACCUMULATION
PLASMALOGEN
Issue Date: 1-Dec-2021
Publisher: SPRINGER
Citation: Watkins, Oliver C, Selvam, Preben, Appukuttan Pillai, Reshma, Cracknell-Hazra, Victoria KB, Yong, Hannah EJ, Sharma, Neha, Cazenave-Gassiot, Amaury, Bendt, Anne K, Godfrey, Keith M, Lewis, Rohan M, Wenk, Markus R, Chan, Shiao-Yng (2021-12-01). Placental C-13-DHA metabolism and relationship with maternal BMI, glycemia and birthweight. MOLECULAR MEDICINE 27 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s10020-021-00344-w
Abstract: Background: Fetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid metabolism. Maternal hyperglycemia and obesity associate with higher birthweight and fetal DHA insufficiency but the role of placental DHA metabolism is unclear. Methods: Explants from 17 term placenta were incubated with 13C-labeled DHA for 48 h, at 5 or 10 mmol/L glucose treatment, and the production of 17 individual newly synthesized 13C-DHA labeled lipids quantified by liquid chromatography mass spectrometry. Results: Maternal BMI positively associated with 13C-DHA-labeled diacylglycerols, triacylglycerols, lysophospholipids, phosphatidylcholine and phosphatidylethanolamine plasmalogens, while maternal fasting glycemia positively associated with five 13C-DHA triacylglycerols. In turn, 13C-DHA-labeled phospholipids and triacylglycerols positively associated with birthweight centile. In-vitro glucose treatment increased most 13C-DHA-lipids, but decreased 13C-DHA phosphatidylethanolamine plasmalogens. However, with increasing maternal BMI, the magnitude of the glucose treatment induced increase in 13C-DHA phosphatidylcholine and 13C-DHA lysophospholipids was curtailed, with further decline in 13C-DHA phosphatidylethanolamine plasmalogens. Conversely, with increasing birthweight centile glucose treatment induced increases in 13C-DHA triacylglycerols were exaggerated, while glucose treatment induced decreases in 13C-DHA phosphatidylethanolamine plasmalogens were diminished. Conclusions: Maternal BMI and glycemia increased the production of different placental DHA lipids implying impact on different metabolic pathways. Glucose-induced elevation in placental DHA metabolism is moderated with higher maternal BMI. In turn, findings of associations between many DHA lipids with birthweight suggest that BMI and glycemia promote fetal growth partly through changes in placental DHA metabolism.
Source Title: MOLECULAR MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/230140
ISSN: 10761551
15283658
DOI: 10.1186/s10020-021-00344-w
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