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Title: Treatment of chronic hepatitis C in patients with end-stage renal disease and hemophilia the Singapore experience
Authors: Chow, WC 
Tien, SL 
Tan, CK 
Lui, HF
Vathsala, A 
Ng, HS 
Keywords: Science & Technology
Life Sciences & Biomedicine
hepatitis C virus
renal failure
thyroid dysfunction
Issue Date: 1-Jan-2005
Publisher: KARGER
Citation: Chow, WC, Tien, SL, Tan, CK, Lui, HF, Vathsala, A, Ng, HS (2005-01-01). Treatment of chronic hepatitis C in patients with end-stage renal disease and hemophilia the Singapore experience. INTERVIROLOGY 49 (1-2) : 107-111. ScholarBank@NUS Repository.
Abstract: Objective: The aim of this study was to determine the response to treatment with interferon-alpha (IFN-α) in patients with chronic hepatitis C who had end-stage renal disease (ESRD) or hemophilia in Singapore. Methods: Treatment-naive hepatitis patients with ESRD or hemophilia were given IFN-α2a 3 million units three times per week for 12 months in an open-label study. Hepatitis C virus RNA was determined before treatment, at the end of treatment and 6 months thereafter. Regular clinical examinations including blood counts and biochemistry were carried out during and after the treatment. Results: Nine consecutive patients with ESRD (8 men and 1 woman) and 6 consecutive male patients with hemophilia, with a mean age of 43 and 40 years, received treatment. Patients in both groups were predominantly infected with hepatitis C virus genotype 1 and had significant cytopenia affecting all three cell lines during the treatment; only 1 patient developed serious neutropenia, temporarily demanding a reduction of his IFN dose. Biochemical and virological responses at the end of treatment were accomplished by 8 of the 9 (89%) patients with ESRD and 4 of the 6 (67%) patients with hemophilia; however, 1 patient with ESRD and 2 with hemophilia relapsed after the treatment. Four of the 7 patients with ESRD who had sustained virological response underwent successful kidney transplantation later on. Conclusion: Monotherapy with IFN-α for 12 months is safe for treatment of the patients with chronic hepatitis C who had ESRD or those with hemophilia. A higher sustained virological response rate was observed in patients with ESRD than in those with hemophilia (78 vs. 33%). Copyright © 2006 S. Karger AG.
ISSN: 03005526
DOI: 10.1159/000087272
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