Please use this identifier to cite or link to this item: https://doi.org/10.1097/MD.0000000000016124
Title: Quality of reporting on thoracic radiotherapy technique in prospective lung cancer trials A systematic review
Authors: Soon, Yu Yang 
Chen, Desiree
Tan, Teng Hwee
Tey, Jeremy Chee Seong 
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
clinical trials
lung cancer
quality of reporting
radiotherapy
RANDOMIZED CONTROLLED-TRIALS
OAT-CELL-CARCINOMA
RADIATION-THERAPY
ONCOLOGY
SURVIVAL
OUTCOMES
Issue Date: 1-Jun-2019
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Soon, Yu Yang, Chen, Desiree, Tan, Teng Hwee, Tey, Jeremy Chee Seong (2019-06-01). Quality of reporting on thoracic radiotherapy technique in prospective lung cancer trials A systematic review. MEDICINE 98 (26). ScholarBank@NUS Repository. https://doi.org/10.1097/MD.0000000000016124
Abstract: BACKGROUND: The aim of this study is to assess the quality of reporting of thoracic (T) RT technique for curative intent treatment in prospective lung cancer trials. METHODS: We searched MEDLINE for eligible trials published from 1996 to 2016. We assessed the included trials' reports on whether they reported the RT dose prescription method; RT dose-planning procedures; algorithm for tissue inhomogeneity dose corrections; organs at risk dose constraints; target volume definition, simulation and/or motion management procedures; treatment verification procedures; total RT dose; fractionation schedule; conduct of quality assurance as well as presence or absence of deviations in RT treatment planning and delivery adequately. We performed univariable and multivariable logistic regression to determine the factors that may influence the quality of reporting. RESULTS: We found 85 eligible trial reports. Target volume definition, total RT dose, and fractionation schedules were reported adequately in more than 90% of the included trials. Algorithm for tissue inhomogeneity dose corrections, simulation and verification procedures, presence or absence of deviations in RT treatment planning and delivery were reported adequately in less than 20% of the included trials. Twenty-three trials (27%) reported 7 criteria or more adequately. Both univariable and multivariable logistic regression showed that trials with RT focused research question were more likely to have adequate quality in reporting (judged as adequate reporting in 7 criteria or more) than trials with non-RT focused question (odds ratio 4.11, 95% confidence interval 1.10 to 15.43, P value = .04). CONCLUSION: There is significant variability in the quality of reporting on thoracic radiotherapy treatment in prospective lung cancer trials. Future research should focus on developing consensus guidelines to standardize the reporting of radiotherapy technique in clinical trials.
Source Title: MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/229777
ISSN: 00257974
15365964
DOI: 10.1097/MD.0000000000016124
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