Please use this identifier to cite or link to this item: https://doi.org/10.1097/00007890-198907000-00009
Title: Lipid abnormalities in cyclosporine-prednisone-treated renal transplant recipients
Authors: Vathsala, A 
Weinberg, RB
Schoenberg, L
Grevel, J
Goldstein, RA
Van Buren, CT
Lewis, RM
Kahan, BD
Keywords: Adult
Cholesterol, LDL
Cyclosporins
Diabetes Mellitus
Female
Humans
Hyperlipidemias
Kidney
Kidney Transplantation
Longitudinal Studies
Male
Middle Aged
Obesity
Prednisone
Statistics as Topic
Time Factors
Transplantation, Homologous
Triglycerides
Issue Date: 1-Jan-1989
Publisher: Ovid Technologies (Wolters Kluwer Health)
Citation: Vathsala, A, Weinberg, RB, Schoenberg, L, Grevel, J, Goldstein, RA, Van Buren, CT, Lewis, RM, Kahan, BD (1989-01-01). Lipid abnormalities in cyclosporine-prednisone-treated renal transplant recipients. Transplantation 48 (1) : 37-43. ScholarBank@NUS Repository. https://doi.org/10.1097/00007890-198907000-00009
Abstract: Hyperlipidemia and hypertension, two major risk factors for accelerated atherosclerosis, undoubtedly contribute to the excessive cardiovascular morbidity and mortality experienced by renal transplant recipients. The present survey of posttransplant hyperlipidemia in 500 cyclosporine-treated patients documented a 37.6% incidence of hypercholesterolemia, which occurred within 6 months posttransplant in 82% of patients. An etiologic relation to corticosteroid therapy was suggested by the strong correlation between prednisone doses and cholesterol levels, by the reduced cholesterol levels in patients undergoing steroid withdrawal, and by the reduction in hypercholesterolemia to 13% by 3 years posttransplant when steroid doses were less than 10 mg daily. Hypertriglyceridemia, which was present in 14.7% of the patients, was more severe under CsA-prednisone compared with azathioprine-prednisone therapy. Hypertriglyceridemia, which occurred later in the posttransplant course than hypercholesterolemia, strongly correlated with an excessive percent relative weight and elevated serum creatinine but not with steroid or CsA doses. Increasing age, diabetes mellitus, З-blockers and nephrotic syndrome contribute to posttransplant hyperlipidemia in the CsA-Pred era as they did in the azathioprine era of immunosuppression. © 1989 by The Williams& Wilkins Co.
Source Title: Transplantation
URI: https://scholarbank.nus.edu.sg/handle/10635/229629
ISSN: 00411337
15346080
DOI: 10.1097/00007890-198907000-00009
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