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https://doi.org/10.1111/j.1600-6143.2010.03303.x
Title: | Native renal cysts and dialysis duration are risk factors for renal cell carcinoma in renal transplant recipients | Authors: | Goh, A Vathsala, A |
Keywords: | Adult Aged Carcinoma, Renal Cell Female Humans Kidney Kidney Diseases, Cystic Kidney Neoplasms Kidney Transplantation Male Middle Aged Renal Dialysis Risk Factors Treatment Outcome Ultrasonography |
Issue Date: | 1-Jan-2011 | Publisher: | Wiley | Citation: | Goh, A, Vathsala, A (2011-01-01). Native renal cysts and dialysis duration are risk factors for renal cell carcinoma in renal transplant recipients. American Journal of Transplantation 11 (1) : 86-92. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1600-6143.2010.03303.x | Abstract: | Urinary tract cancers are the third most common cancers in renal transplant recipients (RTX). This study examined the impact of dialysis duration and native renal cyst(s) (NRC) on renal cell carcinoma (RCC) occurrence among 1036 RTX followed-up from 1995 to July 2007. Abdominal ultrasonography was planned within 1-month of transplant, then every 5 years, or 2 years if renal cysts developed. Based on presence and time of development of NRC, RTX were grouped into those with no (No-NRC), new (New-NRC), preexisting (Pre-NRC) and time-indeterminate NRC (TI-NRC). Ten asymptomatic RTX were diagnosed with RCC at a median of 5.8 years posttransplant and had 5-year graft and patient survivals of 90% and 100%, respectively, following appropriate therapy. RCC occurred only in Pre-NRC and TI-NRC who had significantly longer dialysis duration than No- or New-NRC (6.7 ± 3.9 and 3.3 ± 3.2 vs. 2.7 ± 3.1 and 2.6 ± 2.4 years, respectively). These results suggest that NRC and increased dialysis duration are risk factors for RCC posttransplant. Since early treatment of RCC gives excellent outcomes, regular ultrasonography performed within a month of transplantation, then every 5 years for those without cysts and every 2 years for those with cysts for early detection of RCC is recommended. This study confirms the impact of uremia on the development of native renal cysts, and demonstrates that native renal cysts can be a surrogate marker for the future development of renal cell carcinoma in renal transplant patients who have already been exposed to prolonged periods of uremia. See editorial by Shapiro and Kaplan on page 10. © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons. | Source Title: | American Journal of Transplantation | URI: | https://scholarbank.nus.edu.sg/handle/10635/229424 | ISSN: | 1600-6135 1600-6143 |
DOI: | 10.1111/j.1600-6143.2010.03303.x |
Appears in Collections: | Staff Publications Elements |
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