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https://doi.org/10.3390/cancers13205147
Title: | Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers | Authors: | Li, Boheng Wan, Qin Li, Zhubo Chng, Wee-Joo |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology <p>JAK/STAT</p> lymphoma myeloma inhibitor B-CELL LYMPHOMA CLASSICAL HODGKIN LYMPHOMA JAK-STAT PATHWAY MULTIPLE-MYELOMA CELLS IN-VITRO KAPPA-B ANTITUMOR-ACTIVITY JAK/STAT PATHWAY GENE-REGULATION PHASE-I |
Issue Date: | 1-Oct-2021 | Publisher: | MDPI | Citation: | Li, Boheng, Wan, Qin, Li, Zhubo, Chng, Wee-Joo (2021-10-01). Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers. CANCERS 13 (20). ScholarBank@NUS Repository. https://doi.org/10.3390/cancers13205147 | Abstract: | The Janus kinase (JAK) family are known to respond to extracellular cytokine stimuli and to phosphorylate and activate signal transducers and activators of transcription (STAT), thereby modulating gene expression profiles. Recent studies have highlighted JAK abnormality in inducing over-activation of the JAK/STAT pathway, and that the cytoplasmic JAK tyrosine kinases may also have a nuclear role. A couple of anti-JAK therapeutics have been developed, which effectively harness lymphoid cancer cells. Here we discuss mutations and fusions leading to JAK deregulations, how up-stream nodes drive JAK expression, how classical JAK/STAT pathways are represented in lymphoid malignancies and the noncanonical and nuclear role of JAKs. We also summarize JAK inhibition therapeutics applied alone or synergized with other drugs in treating lymphoid malignancies. | Source Title: | CANCERS | URI: | https://scholarbank.nus.edu.sg/handle/10635/228997 | ISSN: | 20726694 | DOI: | 10.3390/cancers13205147 |
Appears in Collections: | Staff Publications Elements |
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