Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells11060941
Title: Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma
Authors: Zhou, Jianbiao 
Chng, Wee-Joo 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
multiple myeloma
signal transducer and activator of transcription 3 (STAT3)
hallmarks of cancer
targeted therapy
JAK inhibitor
BONE-MARROW MICROENVIRONMENT
SUPER-ANTAGONIST SANT7
KINASE INHIBITOR
DENDRITIC CELLS
TRANSCRIPTION 3
PHASE-I
APOPTOSIS
PRL-3
COMBINATION
PHOSPHATASE
Issue Date: 1-Mar-2022
Publisher: MDPI
Citation: Zhou, Jianbiao, Chng, Wee-Joo (2022-03-01). Biological Hallmarks and Emerging Strategies to Target STAT3 Signaling in Multiple Myeloma. CELLS 11 (6). ScholarBank@NUS Repository. https://doi.org/10.3390/cells11060941
Abstract: Multiple myeloma (MM) is the second most common hematological malignancy, characterized by an abnormal accumulation of plasma cells in the bone marrow. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that modulates the transcription of multiple genes to regulate various principal biological functions, for example, cell proliferation and survival, stemness, inflammation and immune responses. Aberrant STAT3 activation has been identified as a key driver of tumorigenesis in many types of cancers, including MM. Herein, we summarize the current evidence for the role of STAT3 in affecting cancer hallmark traits by: (1) sustaining MM cell survival and proliferation, (2) regulating tumor microenvironment, (3) inducing immunosuppression. We also provide an update of different strategies for targeting STAT3 in MM with special emphasis on JAK inhibitors that are currently undergoing clinical trials. Finally, we discuss the challenges and future direction of understanding STAT3 signaling in MM biology and the clinical development of STAT3 inhibitors.
Source Title: CELLS
URI: https://scholarbank.nus.edu.sg/handle/10635/228991
ISSN: 2073-4409,2073-4409
DOI: 10.3390/cells11060941
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