Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmed.2017.00039
Title: Imprecision in the Era of Precision Medicine in Non-Small Cell Lung Cancer
Authors: Sundar, Raghav 
Chenard-Poirier, Maxime
Collins, Dearbhaile Catherine
Yap, Timothy A
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
precision medicine
lung cancer
targeted therapy
imprecision
clinical trials
RANDOMIZED PHASE-II
PREVIOUSLY TREATED PATIENTS
CISPLATIN PLUS GEMCITABINE
RECEPTOR TYROSINE KINASE
TIVANTINIB ARQ 197
OPEN-LABEL
EGFR MUTATION
1ST-LINE THERAPY
DOUBLE-BLIND
C-MET
Issue Date: 10-Apr-2017
Publisher: FRONTIERS MEDIA SA
Citation: Sundar, Raghav, Chenard-Poirier, Maxime, Collins, Dearbhaile Catherine, Yap, Timothy A (2017-04-10). Imprecision in the Era of Precision Medicine in Non-Small Cell Lung Cancer. FRONTIERS IN MEDICINE 4 (APR). ScholarBank@NUS Repository. https://doi.org/10.3389/fmed.2017.00039
Abstract: Over the past decade, major advances have been made in the management of advanced non-small cell lung cancer (NSCLC). There has been a particular focus on the identification and targeting of putative driver aberrations, which has propelled NSCLC to the forefront of precision medicine. Several novel molecularly targeted agents have now achieved regulatory approval, while many others are currently in late-phase clinical trial testing. These antitumor therapies have significantly impacted the clinical outcomes of advanced NSCLC and provided patients with much hope for the future. Despite this, multiple deficiencies still exist in our knowledge of this complex disease, and further research is urgently required to overcome these critical issues. This review traces the path undertaken by the different therapeutics assessed in NSCLC and the impact of precision medicine in this disease. We also discuss the areas of "imprecision" that still exist in NSCLC and the modern hypothesis-testing studies being conducted to address these key challenges.
Source Title: FRONTIERS IN MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/228507
ISSN: 2296-858X
DOI: 10.3389/fmed.2017.00039
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