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https://doi.org/10.1186/s12879-022-07066-2
Title: | Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups | Authors: | Ang, Li Wei Gao, Qi Cui, Lin Farwin, Aysha Toh, Matthias Paul Han Sim Boudville, Irving Charles Chen, Mark I-Cheng Chow, Angela Lin, Raymond Tzer-Pin Lee, Vernon Jian Ming Leo, Yee Sin |
Keywords: | Science & Technology Life Sciences & Biomedicine Infectious Diseases Measles Immunity Prevalence Vaccination coverage Migrant workers REDUCTION NEUTRALIZATION TEST IMMUNOGENICITY ELIMINATION OUTBREAK DISEASES PROGRESS CHINA |
Issue Date: | 25-Jan-2022 | Publisher: | BMC | Citation: | Ang, Li Wei, Gao, Qi, Cui, Lin, Farwin, Aysha, Toh, Matthias Paul Han Sim, Boudville, Irving Charles, Chen, Mark I-Cheng, Chow, Angela, Lin, Raymond Tzer-Pin, Lee, Vernon Jian Ming, Leo, Yee Sin (2022-01-25). Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups. BMC INFECTIOUS DISEASES 22 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12879-022-07066-2 | Abstract: | Background: In 2019, two clusters of measles cases were reported in migrant worker dormitories in Singapore. We conducted a seroprevalence study to measure the level of susceptibility to measles among migrant workers in Singapore. Methods: Our study involved residual sera of migrant workers from seven Asian countries (Bangladesh, China, India, Indonesia, Malaysia, Myanmar and the Philippines) who had participated in a survey between 2016 and 2019. Immunoglobulin G (IgG) antibody levels were first measured using a commercial enzyme-linked immunosorbent assay (ELISA) test kit. Those with equivocal or negative IgG results were further evaluated using plaque reduction neutralization test (PRNT). Results: A total of 2234 migrant workers aged 20–49 years were included in the study. The overall prevalence of measles IgG antibodies among migrant workers from the seven Asian countries was 90.5% (95% confidence interval 89.2–91.6%). The country-specific seroprevalence ranged from 80.3 to 94.0%. The seroprevalence was significantly higher among migrant workers born in 1965–1989 than those born in 1990–1999 (95.3% vs. 86.6%, p < 0.0005), whereas there was no significant difference by gender (90.8% in men vs. 89.9% in women, p = 0.508). 195 out of 213 samples with equivocal or negative ELISA results were tested positive using PRNT. Conclusion: The IgG seroprevalence in migrant workers was below the herd immunity threshold of 95% for measles. Sporadic outbreaks may occur in susceptible individuals due to high transmissibility of measles virus. Seroprevalence surveys can help identify susceptible subgroups for vaccination. | Source Title: | BMC INFECTIOUS DISEASES | URI: | https://scholarbank.nus.edu.sg/handle/10635/228438 | ISSN: | 14712334 | DOI: | 10.1186/s12879-022-07066-2 |
Appears in Collections: | Staff Publications Elements |
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