Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12879-022-07066-2
Title: Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups
Authors: Ang, Li Wei
Gao, Qi
Cui, Lin 
Farwin, Aysha 
Toh, Matthias Paul Han Sim 
Boudville, Irving Charles
Chen, Mark I-Cheng 
Chow, Angela 
Lin, Raymond Tzer-Pin 
Lee, Vernon Jian Ming 
Leo, Yee Sin 
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Measles
Immunity
Prevalence
Vaccination coverage
Migrant workers
REDUCTION NEUTRALIZATION TEST
IMMUNOGENICITY
ELIMINATION
OUTBREAK
DISEASES
PROGRESS
CHINA
Issue Date: 25-Jan-2022
Publisher: BMC
Citation: Ang, Li Wei, Gao, Qi, Cui, Lin, Farwin, Aysha, Toh, Matthias Paul Han Sim, Boudville, Irving Charles, Chen, Mark I-Cheng, Chow, Angela, Lin, Raymond Tzer-Pin, Lee, Vernon Jian Ming, Leo, Yee Sin (2022-01-25). Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups. BMC INFECTIOUS DISEASES 22 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s12879-022-07066-2
Abstract: Background: In 2019, two clusters of measles cases were reported in migrant worker dormitories in Singapore. We conducted a seroprevalence study to measure the level of susceptibility to measles among migrant workers in Singapore. Methods: Our study involved residual sera of migrant workers from seven Asian countries (Bangladesh, China, India, Indonesia, Malaysia, Myanmar and the Philippines) who had participated in a survey between 2016 and 2019. Immunoglobulin G (IgG) antibody levels were first measured using a commercial enzyme-linked immunosorbent assay (ELISA) test kit. Those with equivocal or negative IgG results were further evaluated using plaque reduction neutralization test (PRNT). Results: A total of 2234 migrant workers aged 20–49 years were included in the study. The overall prevalence of measles IgG antibodies among migrant workers from the seven Asian countries was 90.5% (95% confidence interval 89.2–91.6%). The country-specific seroprevalence ranged from 80.3 to 94.0%. The seroprevalence was significantly higher among migrant workers born in 1965–1989 than those born in 1990–1999 (95.3% vs. 86.6%, p < 0.0005), whereas there was no significant difference by gender (90.8% in men vs. 89.9% in women, p = 0.508). 195 out of 213 samples with equivocal or negative ELISA results were tested positive using PRNT. Conclusion: The IgG seroprevalence in migrant workers was below the herd immunity threshold of 95% for measles. Sporadic outbreaks may occur in susceptible individuals due to high transmissibility of measles virus. Seroprevalence surveys can help identify susceptible subgroups for vaccination.
Source Title: BMC INFECTIOUS DISEASES
URI: https://scholarbank.nus.edu.sg/handle/10635/228438
ISSN: 14712334
DOI: 10.1186/s12879-022-07066-2
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