Please use this identifier to cite or link to this item: https://doi.org/10.3390/ph15060718
Title: Enhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study.
Authors: Sia, Ching-Hui 
Tan, Sock-Hwee 
Chan, Siew-Pang 
Marchesseau, Stephanie 
Sim, Hui-Wen
Carvalho, Leonardo 
Chen, Ruth
Amin, Nor Hanim Mohd
Fong, Alan Yean-Yip
Richards, Arthur Mark 
Yip, Christina
Chan, Mark Y 
Keywords: ST-segment elevation myocardial infarction
adverse ventricular remodeling
cardiovascular magnetic resonance imaging
percutaneous coronary intervention
thrombolysis
Issue Date: 6-Jun-2022
Publisher: MDPI AG
Citation: Sia, Ching-Hui, Tan, Sock-Hwee, Chan, Siew-Pang, Marchesseau, Stephanie, Sim, Hui-Wen, Carvalho, Leonardo, Chen, Ruth, Amin, Nor Hanim Mohd, Fong, Alan Yean-Yip, Richards, Arthur Mark, Yip, Christina, Chan, Mark Y (2022-06-06). Enhanced Thrombin Generation Is Associated with Worse Left Ventricular Scarring after ST-Segment Elevation Myocardial Infarction: A Cohort Study.. Pharmaceuticals (Basel) 15 (6) : 718-. ScholarBank@NUS Repository. https://doi.org/10.3390/ph15060718
Abstract: Acute myocardial infarction (AMI) is associated with heightened thrombin generation. There are limited data relating to thrombin generation and left ventricular (LV) scarring and LV dilatation in post-MI LV remodeling. We studied 113 patients with ST-segment elevation myocardial infarction (STEMI) who had undergone primary percutaneous coronary intervention (PPCI) (n = 76) or pharmaco-invasive management (thrombolysis followed by early PCI, n = 37). Endogenous thrombin potential (ETP) was measured at baseline, 1 month and 6 months. Cardiovascular magnetic resonance imaging was performed at baseline and 6 months post-MI. Outcomes studied were an increase in scar change, which was defined as an increase in left ventricular infarct size of any magnitude detected by late gadolinium enhancement, adverse LV remodeling, defined as dilatation (increase) of left ventricular end-diastolic volume (LVEDV) by more than 20% and an increase in left ventricular ejection fraction (LVEF). The mean age was 55.19 ± 8.25 years and 91.2% were men. The baseline ETP was similar in the PPCI and pharmaco-invasive groups (1400.3 nM.min vs. 1334.1 nM.min, p = 0.473). Each 10-unit increase in baseline ETP was associated with a larger scar size (adjusted OR 1.020, 95% CI 1.002-1.037, p = 0.027). Baseline ETP was not associated with adverse LV remodeling or an increase in LVEF. There was no difference in scar size or adverse LV remodeling among patients undergoing PPCI vs. pharmaco-invasive management or patients receiving ticagrelor vs. clopidogrel. Enhanced thrombin generation after STEMI is associated with a subsequent increase in myocardial scarring but not LV dilatation or an increase in LVEF at 6 months post-MI.
Source Title: Pharmaceuticals (Basel)
URI: https://scholarbank.nus.edu.sg/handle/10635/228343
ISSN: 14248247
DOI: 10.3390/ph15060718
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