Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0244417
Title: The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2
Authors: Tan, Seow Yen
Tey, Hong Liang 
Lim, Ernest Tian Hong
Toh, Song Tar 
Chan, Yiong Huak 
Tan, Pei Ting 
Lee, Sing Ai
Tan, Cheryl Xiaotong
Koh, Gerald Choon Huat 
Tan, Thean Yen 
Siau, Chuin 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Issue Date: 16-Dec-2020
Publisher: PUBLIC LIBRARY SCIENCE
Citation: Tan, Seow Yen, Tey, Hong Liang, Lim, Ernest Tian Hong, Toh, Song Tar, Chan, Yiong Huak, Tan, Pei Ting, Lee, Sing Ai, Tan, Cheryl Xiaotong, Koh, Gerald Choon Huat, Tan, Thean Yen, Siau, Chuin (2020-12-16). The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2. PLOS ONE 15 (12). ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0244417
Abstract: Background Self-sampling for SARS-CoV-2 would significantly raise testing capacity and reduce healthcare worker (HCW) exposure to infectious droplets personal, and protective equipment (PPE) use. Methods We conducted a diagnostic accuracy study where subjects with a confirmed diagnosis of COVID-19 (n = 401) and healthy volunteers (n = 100) were asked to self-swab from their oropharynx and mid-turbinate (OPMT), and self-collect saliva. The results of these samples were compared to an OPMT performed by a HCW in the same patient at the same session. Results In subjects confirmed to have COVID-19, the sensitivities of the HCW-swab, self-swab, saliva, and combined self-swab plus saliva samples were 82.8%, 75.1%, 74.3% and 86.5% respectively. All samples obtained from healthy volunteers were tested negative. Compared to HCW-swab, the sensitivities of a self-swab sample and saliva sample were inferior by 8.7% (95%CI: 2.4% to 15.0%, p = 0.006) and 9.5% (95%CI: 3.1% to 15.8%, p = 0.003) respectively. The combined detection rate of self-swab and saliva had a sensitivity of 2.7% (95%CI: -2.6% to 8.0%, p = 0.321). The sensitivity of both the self-collection methods are higher when the Ct value of the HCW swab is less than 30. The specificity of both the selfswab and saliva testing was 100% (95% CI 96.4% to 100%). Conclusion Our study provides evidence that sensitivities of self-collected OPMT swab and saliva samples were inferior to a HCW swab, but they could still be useful testing tools in the appropriate clinical settings. Copyright:
Source Title: PLOS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/228121
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0244417
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