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Title: Allergens and their associated small molecule ligands-their dual role in sensitization
Authors: Chruszcz, Maksymilian
Chew, Fook Tim 
Hoffmann-Sommergruber, Karin
Hurlburt, Barry K
Mueller, Geoffrey A
Pomes, Anna
Rouvinen, Juha
Villalba, Mayte
Woehrl, Birgitta M
Breiteneder, Heimo
Keywords: group 2 house dust mite allergens
serum albumin
Issue Date: 2-May-2021
Publisher: WILEY
Citation: Chruszcz, Maksymilian, Chew, Fook Tim, Hoffmann-Sommergruber, Karin, Hurlburt, Barry K, Mueller, Geoffrey A, Pomes, Anna, Rouvinen, Juha, Villalba, Mayte, Woehrl, Birgitta M, Breiteneder, Heimo (2021-05-02). Allergens and their associated small molecule ligands-their dual role in sensitization. ALLERGY 76 (8) : 2367-2382. ScholarBank@NUS Repository.
Abstract: Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic small-molecule ligands. Ligand-binding specificities can be strict or promiscuous. Serum albumins from mammals and birds can assume multiple conformations that facilitate the binding of a broad spectrum of compounds. Pollen and plant food allergens of the family 10 of pathogenesis-related proteins bind a variety of small molecules such as glycosylated flavonoid derivatives, flavonoids, cytokinins, and steroids in vitro. However, their natural ligand binding was reported to be highly specific. Insect and mammalian lipocalins transport odorants, pheromones, catecholamines, and fatty acids with a similar level of specificity, while the food allergen β-lactoglobulin from cow's milk is notably more promiscuous. Non-specific lipid transfer proteins from pollen and plant foods bind a wide variety of lipids, from phospholipids to fatty acids, as well as sterols and prostaglandin B2, aided by the high plasticity and flexibility displayed by their lipid-binding cavities. Ligands increase the stability of allergens to thermal and/or proteolytic degradation. They can also act as immunomodulatory agents that favor a Th2 polarization. In summary, ligand-binding allergens expose the immune system to a variety of biologically active compounds whose impact on the sensitization process has not been well studied thus far.
Source Title: ALLERGY
ISSN: 0105-4538
DOI: 10.1111/all.14861
Appears in Collections:Staff Publications

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