Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ajps.2017.04.003
Title: Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box–Behnken design
Authors: Liu, S 
Ho, PC 
Keywords: Box–Behnken design
Chitosan
HP-β-CD
Nanoparticles
Response surface methodology
Scutellarin
Issue Date: 1-Jul-2017
Publisher: Elsevier BV
Citation: Liu, S, Ho, PC (2017-07-01). Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box–Behnken design. Asian Journal of Pharmaceutical Sciences 12 (4) : 378-385. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ajps.2017.04.003
Abstract: The aim of this paper is to investigate and optimize the preparation of scutellarin (SCU)-loaded HP-β-CD/chitosan (CS) nanoparticles (CD/CS-SCU-NPs). CD/CS-SCU-NPs were prepared by ionic cross-linking method and the process and formulation variables were optimized using response surface methodology (RSM) with a three-level, three factor Box–Behnken design (BBD). The independent variables were the added amounts of CS, sodium tripolyphosphate (TPP) and Pluronic F-68 during the preparation. Dependent variables (responses) were particle size and entrapment efficiency. Mathematical equations and respond surface plots were used to correlate independent and dependent variables. The preparation process and formulation variables were optimized to achieve minimum particle size and maximum entrapment efficiency by calculating the overall desirability value (OD). The optimized NP formulation was characterized for particle size, PDI, zeta potential, entrapment efficiency and in vitro drug release. According to the results, an optimized CD/CS-SCU-NP formulation was prepared. Results for particle size, PDI, zeta potential and entrapment efficiency were found to be around 200 nm, 0.5, 25 mV, and 70% respectively. For in vitro study, the release of SCU from the NPs exhibited a biphasic release and was in accordance with Higuchi equation. The optimized preparation was simple with the probability for industrialization. The combination use of RSM, BBD and overall desirability values could provide a promising application for incorporating CD into CS nanoparticles as drug delivery carrier and help develop lab-scale procedures.
Source Title: Asian Journal of Pharmaceutical Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/226878
ISSN: 1818-0876
2221-285X
DOI: 10.1016/j.ajps.2017.04.003
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Formulation optimization of scutellarin-loaded HP-β-CDchitosan nanoparticles using response surface methodology with Box-Beh.pdf1.18 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

20
checked on Sep 23, 2022

Page view(s)

30
checked on Sep 22, 2022

Download(s)

1
checked on Sep 22, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.